Effects of Empagliflozin Treatment on Glycerol‐Derived Hepatic Gluconeogenesis in Adults with Obesity: A Randomized Clinical Trial
Sign Up to like & getrecommendations! Published in 2020 at "Obesity"
DOI: 10.1002/oby.22854
Abstract: The aim of this study was to determine the effects of empagliflozin on glycerol‐derived hepatic gluconeogenesis in adults with obesity without type 2 diabetes mellitus (T2DM) using oral carbon 13 (13C)‐labeled glycerol. read more here.
Keywords: glycerol derived; derived hepatic; glycerol; hepatic gluconeogenesis ... See more keywords
Adenine base editing and prime editing of chemically derived hepatic progenitors rescue genetic liver disease.
Sign Up to like & getrecommendations! Published in 2021 at "Cell stem cell"
DOI: 10.1016/j.stem.2021.04.010
Abstract: DNA base editors and prime editing technology enable therapeutic in situ correction of disease-causing alleles. These techniques could have broad applications for ex vivo editing of cells prior to transplantation in a range of diseases, but… read more here.
Keywords: derived hepatic; hepatic progenitors; disease; base ... See more keywords
Blood-derived macrophages prone to accumulate lysosomal lipids trigger oxLDL-dependent murine hepatic inflammation
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DOI: 10.1038/s41598-017-13058-z
Abstract: Despite the consistent rise of non-alcoholic steatohepatitis (NASH) worldwide, the mechanisms that govern the inflammatory aspect of this disease remain unknown. Previous research showed an association between hepatic inflammation and lysosomal lipid accumulation in blood-derived… read more here.
Keywords: hepatic inflammation; derived hepatic; inflammation; lysosomal lipids ... See more keywords
A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features.
Sign Up to like & getrecommendations! Published in 2017 at "Stem cells and development"
DOI: 10.1089/scd.2017.0023
Abstract: The quest for physiologically active human hepatocyte-like cells for in vitro research and drug screening is high. The recent progress in the field of pluripotent stem cell (PSC)-derived hepatic cells within the last decade brings… read more here.
Keywords: derived hepatic; generation; hepatic organoids; stem ... See more keywords