Bioinspired Artificial Liver System with hiPSC-derived Hepatocytes for Acute Liver Failure Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101580
Abstract: Bioartificial liver (BAL) system has become a promising alternative to traditional liver transplantation in rescuing acute liver failure (ALF) patients. Herein, inspired by natural microstructure of hepatic lobules, we developed a novel biomimetic bioartificial liver… read more here.
Keywords: derived hepatocytes; liver failure; system; acute liver ... See more keywords
Nutrient environment improves drug metabolic activity in human iPSC-derived hepatocytes and HepG2
Sign Up to like & getrecommendations! Published in 2025 at "Archives of Toxicology"
DOI: 10.1007/s00204-025-04139-4
Abstract: Induced pluripotent stem cells (iPSCs) have emerged as a transformative tool in regenerative medicine, in liver research. The perspective of a stable and functional source of hepatocytes has led to developing protocols for human iPSC-derived… read more here.
Keywords: human ipsc; drug; derived hepatocytes; ipsc derived ... See more keywords
Prediction of hepatotoxicity for drugs using human pluripotent stem cell-derived hepatocytes
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biology and Toxicology"
DOI: 10.1007/s10565-017-9392-y
Abstract: Drug-induced liver toxicity is a main reason for withdrawals of new drugs in late clinical phases and post-launch of the drugs. Thus, hepatotoxicity screening of drug candidates in pre-clinical stage is important for reducing drug… read more here.
Keywords: derived hepatocytes; drug; hepatotoxicity; stem ... See more keywords
iPSC-derived hepatocytes generated from NASH donors provide a valuable platform for disease modeling and drug discovery.
Sign Up to like & getrecommendations! Published in 2020 at "Biology open"
DOI: 10.1242/bio.055087
Abstract: Non-alcoholic fatty liver disease (NAFLD) affects 30 to 40% of adults and 10% of children in the US. About 20% of people with NAFLD develop non-alcoholic steatohepatitis (NASH), which may lead to cirrhosis and liver… read more here.
Keywords: derived hepatocytes; donors provide; nash donors; biology ... See more keywords