Tumor-derived high-mobility group box 1 and thymic stromal lymphopoietin are involved in modulating dendritic cells to activate T regulatory cells in a mouse model
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DOI: 10.1007/s00262-017-2087-7
Abstract: High-mobility group box 1 (HMGB1) is involved in the tumor-associated activation of regulatory T cells (Treg), but the mechanisms remain unknown. In a mouse tumor model, silencing HMGB1 in tumor cells or inhibiting tumor-derived HMGB1… read more here.
Keywords: derived hmgb1; high mobility; tumor derived; tslp ... See more keywords
Abstract 7240: The role of myeloid cell derived HMGB1 in the development of hepatocellular carcinoma
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DOI: 10.1158/1538-7445.am2025-7240
Abstract: High mobility group box 1 (HMGB1) is a non-histone chromatin-associated protein involved in the pathogenesis of chronic liver disease. HMGB1 is expressed in myeloid cells, including conventional dendritic cells (cDCs), which play a major role… read more here.
Keywords: derived hmgb1; mice; myemice; tumor ... See more keywords