Functional evaluation of the tachycardia patient‐derived iPSC cardiomyocytes carrying a novel pathogenic SCN5A variant
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30843
Abstract: Tachycardia is characterized by high beating rates that can lead to life‐threatening fibrillations. Mutations in several ion‐channel genes were implicated with tachycardia; however, the complex genetic contributors and their modes of action are still unclear.… read more here.
Keywords: scn5a; ipsc cms; tachycardia; derived ipsc ... See more keywords
Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone Responses.
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DOI: 10.1016/j.stem.2018.03.009
Abstract: The hypothalamus contains neurons that integrate hunger and satiety endocrine signals from the periphery and are implicated in the pathophysiology of obesity. The limited availability of human hypothalamic neurons hampers our understanding of obesity disease… read more here.
Keywords: hypothalamic neurons; obese patient; super obese; obesity ... See more keywords
Patient-Derived iPSC-Hypothamic Neurons: The Ultimate Protocol.
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DOI: 10.1016/j.stem.2018.04.019
Abstract: Several methods for making hypothalamic-like neurons (iHTNs) from human or mouse induced pluripotent stem cells (iPSCs) with varying efficiencies exist. In this issue of Cell Stem Cell, Rajamani et al. (2018) devise a new, efficient method… read more here.
Keywords: neurons ultimate; hypothamic neurons; ultimate protocol; ipsc hypothamic ... See more keywords