CALR frameshift mutations in MPN patient-derived iPSCs accelerate maturation of megakaryocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Stem cell reports"
DOI: 10.1016/j.stemcr.2021.09.019
Abstract: Calreticulin (CALR) mutations are driver mutations in myeloproliferative neoplasms (MPNs), leading to activation of the thrombopoietin receptor and causing abnormal megakaryopoiesis. Here, we generated patient-derived CALRins5- or CALRdel52-positive induced pluripotent stem cells (iPSCs) to establish… read more here.
Keywords: derived ipscs; frameshift mutations; calr frameshift; mpn patient ... See more keywords
Abstract LB363: Patient-derived iPSCs faithfully represent the genetic diversity and cellular architecture of human acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb363
Abstract: The reprogramming of malignant cells to pluripotency has presented considerable challenges, hindering the application of induced pluripotent stem cell (iPSC) modeling technology to human cancers. In addition, how well iPSC-derived cells resemble their primary counterparts… read more here.
Keywords: ipsc derived; myeloid leukemia; derived ipscs; patient ... See more keywords
Osteochondral Tissue Chip Derived From iPSCs: Modeling OA Pathologies and Testing Drugs
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2019.00411
Abstract: Osteoarthritis (OA) is a chronic disease mainly characterized by degenerative changes in cartilage, but other joint elements such as bone are also affected. To date, there are no disease-modifying OA drugs (DMOADs), owing in part… read more here.
Keywords: osteochondral tissue; chip derived; tissue chip; derived ipscs ... See more keywords