MyD88 and not TRIF knockout is sufficient to abolish LPS‐induced inflammatory responses in bone‐derived macrophages
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14616
Abstract: Macrophages play an important role in the response to infection and/or repair of injury in tissues. To examine the NF‐κB pathway in response to an inflammatory stimulus, we used wild‐type bone‐marrow‐derived macrophages (BMDMs) or BMDMs… read more here.
Keywords: trif; derived macrophages; myd88 trif; knockout ... See more keywords
Distinct spatiotemporal features of microglia and monocyte‐derived macrophages in glioma
Sign Up to like & getrecommendations! Published in 2023 at "European Journal of Immunology"
DOI: 10.1002/eji.202250161
Abstract: Gliomas are the most frequent primary tumors of the brain. Glioma progression is regulated by the tumor microenvironment, which is mainly composed of tumor‐associated microglia (TA‐MG) and monocyte‐derived macrophages (MDM). Recent studies have highlighted the… read more here.
Keywords: spatiotemporal features; derived macrophages; progression; monocyte derived ... See more keywords
The SC cell line as an in vitro model of human monocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of leukocyte biology"
DOI: 10.1002/jlb.1a1221-680r
Abstract: In vitro analysis of human macrophages is generally hampered by the necessity to differentiate them from peripheral blood monocytes. We have analyzed to which extent noncancerous SC monocytes could be used as an in vitro… read more here.
Keywords: expression; cell line; monocyte derived; derived macrophages ... See more keywords
Highly restricted SARS‐CoV‐2 receptor expression and resistance to infection by primary human monocytes and monocyte‐derived macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4cova1121-579rr
Abstract: Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS‐CoV2), which causes the disease COVID‐19, has caused an unprecedented global pandemic. Angiotensin‐converting enzyme 2 (ACE2) is the major cellular receptor for SARS‐CoV2 entry, which is facilitated by… read more here.
Keywords: sars cov2; derived macrophages; infection; monocyte derived ... See more keywords
Generation of Bone Marrow-Derived Macrophages for In Vitro Infection Experiments.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9210-2_12
Abstract: Murine bone marrow-derived macrophages (BMMs) can be differentiated within 10 days from ex vivo bone marrow progenitor cells by supplementing the cell growth medium with colony stimulating factor-1 (CSF-1). Mature macrophages express specific myeloid markers… read more here.
Keywords: marrow derived; bone; derived macrophages; vitro infection ... See more keywords
Use of Human Monocyte-Derived Macrophages to Study Neisseria gonorrhoeae Infection.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9496-0_18
Abstract: Macrophages are critical cells in the innate immune response to microorganisms sensed in the tissues. During infections, the interaction between pathogens and macrophages leads to a macrophage response that includes cytokine production, antigen processing and… read more here.
Keywords: response; infection; human monocyte; neisseria gonorrhoeae ... See more keywords
M2-like polarization of THP-1 monocyte-derived macrophages under chronic iron overload
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Hematology"
DOI: 10.1007/s00277-020-03916-8
Abstract: Macrophages are characterized by phenotypical and functional heterogeneity. In different microenvironments, macrophages can polarize into two types: classically activated macrophages (M1) or alternatively activated macrophages (M2). M1 macrophages are a well-known bacteriostatic macrophage, and conversely,… read more here.
Keywords: chronic iron; thp; iron overload; derived macrophages ... See more keywords
Endocardially Derived Macrophages Are Essential for Valvular Remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.01.021
Abstract: During mammalian embryogenesis, de novo hematopoiesis occurs transiently in multiple anatomical sites including the yolk sac, dorsal aorta, and heart tube. A long-unanswered question is whether these local transient hematopoietic mechanisms are essential for embryonic… read more here.
Keywords: endocardially derived; essential valvular; tissue macrophages; derived macrophages ... See more keywords
Ursodeoxycholyl lysophosphatidylethanolamide negatively regulates TLR‐mediated lipopolysaccharide response in human THP‐1‐derived macrophages
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.02.030
Abstract: Abstract The bile acid‐phospholipid conjugate ursodeoxycholyl oleoyl‐lysophophatidylethanolamide (UDCA‐18:1LPE) is an anti‐inflammatory and anti‐fibrotic agent as previously shown in cultured hepatocytes and hepatic stellate cells as well as in in vivo models of liver injury. We… read more here.
Keywords: anti inflammatory; response; udca 1lpe; derived macrophages ... See more keywords
A novel role for SHARPIN in amyloid-β phagocytosis and inflammation by peripheral blood-derived macrophages in Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.02.001
Abstract: Defective immune cell-mediated clearance of amyloid-beta (Aβ) and Aβ-associated inflammatory activation of immune cells are key contributors in pathogenesis of Alzheimer's disease (AD). However, the underlying mechanisms remain elusive. Shank-associated RH domain-interacting protein (SHARPIN) is… read more here.
Keywords: phagocytosis; alzheimer disease; blood; sharpin ... See more keywords
iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.07.006
Abstract: Summary Induced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly attractive source for cell and gene therapy. Given the longevity, plasticity, and self-renewal potential of distinct macrophage subpopulations, iPSC-derived macrophages (iPSC-Mφ) appear of particular… read more here.
Keywords: pulmonary alveolar; alveolar proteinosis; ipsc derived; derived macrophages ... See more keywords