Structure–Activity Relationships of 8-Hydroxyquinoline-Derived Mannich Bases with Tertiary Amines Targeting Multidrug-Resistant Cancer
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DOI: 10.1021/acs.jmedchem.2c00076
Abstract: A recently proposed strategy to overcome multidrug resistance (MDR) in cancer is to target the collateral sensitivity of otherwise resistant cells. We designed a library of 120 compounds to explore the chemical space around previously… read more here.
Keywords: derived mannich; multidrug; mannich bases; activity ... See more keywords