Gut microbe-derived metabolite trimethylamine N-oxide activates the cardiac autonomic nervous system and facilitates ischemia-induced ventricular arrhythmia via two different pathways
Sign Up to like & getrecommendations! Published in 2019 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.03.066
Abstract: Background We previously demonstrated the gut microbes-derived metabolite trimethylamine N-oxide (TMAO) could activate the atrial autonomic ganglion plexus and promote atrial arrhythmia. The cardiac sympathetic nervous system (CSNS) play important roles in modulating ventricular arrhythmia… read more here.
Keywords: arrhythmia; nervous system; tmao; derived metabolite ... See more keywords
Novel gut microbiota-derived metabolite promotes platelet thrombosis via adrenergic receptor signalling
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DOI: 10.1038/s41569-020-0367-y
Abstract: A novel metabolite derived from gut microbiota has been shown to promote platelet hyper-responsiveness and modulate platelet function via adrenergic receptors, contributing to increased thrombotic risk. read more here.
Keywords: via adrenergic; gut microbiota; novel gut; derived metabolite ... See more keywords
MO185THE GUT MICROBIOME-DERIVED METABOLITE TRIMETHYLAMINE N-OXIDE AS A POTENTIAL BIOMARKER IN LUPUS NEPHRITIS PATIENTS
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DOI: 10.1093/ndt/gfab092.0063
Abstract: Both human and animal studies suggest that the gut microbe-derived metabolite Trimethylamine N-oxide (TMAO) is strongly associated with several autoimmune disease including Rheumatoid arthritis and psoriatic arthropathy. TMAO has been previously studied as a discriminator… read more here.
Keywords: trimethylamine; lupus nephritis; metabolite trimethylamine; derived metabolite ... See more keywords