Human iPSC‐derived microglia: A growing toolset to study the brain's innate immune cells
Sign Up to like & getrecommendations! Published in 2020 at "Glia"
DOI: 10.1002/glia.23781
Abstract: Recent advances in the generation of microglia from human induced pluripotent stem cells (iPSCs) have provided exciting new approaches to examine and decipher the biology of microglia. As these techniques continue to evolve to encompass… read more here.
Keywords: microglia growing; toolset; biology; derived microglia ... See more keywords
Functional analysis of CX3CR1 in human induced pluripotent stem (iPS) cell‐derived microglia‐like cells
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14879
Abstract: Microglia are the primary immune cells of the central nervous system and crucial to proper development and maintenance of the brain. Microglia have been recognized to be associated with neurodegenerative diseases and neuroinflammatory disorders. CX3C… read more here.
Keywords: cx3cr1 human; cell derived; like cells; ips cell ... See more keywords
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq0651
Abstract: The most common genetic mutation found in familial and sporadic amyotrophic lateral sclerosis (ALS), as well as fronto-temporal dementia (FTD), is a repeat expansion in the C9orf72 gene. C9orf72 is highly expressed in human myeloid… read more here.
Keywords: derived microglia; disrupted autophagy; cell autonomous; c9orf72 als ... See more keywords
Particulate matter from car exhaust alters function of human iPSC-derived microglia
Sign Up to like & getrecommendations! Published in 2024 at "Particle and Fibre Toxicology"
DOI: 10.1186/s12989-024-00564-y
Abstract: Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer’s disease.… read more here.
Keywords: function human; human ipsc; particulate matter; derived microglia ... See more keywords
Replacement of Mouse Microglia With Human Induced Pluripotent Stem Cell (hiPSC)-Derived Microglia in Mouse Organotypic Slice Cultures
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.918442
Abstract: Microglia, the major immune cells in the brain, are reported to differ in gene expression patterns among species. Therefore, it would be preferable in some cases to use human microglia rather than mouse microglia in… read more here.
Keywords: derived microglia; mouse; hipsc; slice cultures ... See more keywords
Patient-specific monocyte-derived microglia as a screening tool for neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.355740
Abstract: Microglia, the main driver of neuroinflammation, play a central role in the initiation and exacerbation of various neurodegenerative diseases and are now considered a promising therapeutic target. Previous studies on in vitro human microglia and… read more here.
Keywords: patient specific; derived microglia; monocyte derived; microglia like ... See more keywords
Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia
Sign Up to like & getrecommendations! Published in 2024 at "Neural Regeneration Research"
DOI: 10.4103/nrr.nrr-d-23-01688
Abstract: JOURNAL/nrgr/04.03/01300535-202503000-00031/figure1/v/2024-06-17T092413Z/r/image-tiff Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to… read more here.
Keywords: alzheimer disease; disease; monocyte derived; pro resolving ... See more keywords