Hepatic exosome-derived miR-130a-3p attenuates glucose tolerance via suppressing PHLPP2 gene in adipocyte.
Sign Up to like & getrecommendations! Published in 2019 at "Metabolism: clinical and experimental"
DOI: 10.1016/j.metabol.2019.154006
Abstract: OBJECTIVE Glucose and lipid metabolism disorder is a major risk factor for type II diabetes and cardiovascular diseases. Evidence has indicated that the interplay between the liver and adipose tissue is crucial in maintaining energy… read more here.
Keywords: hepatic exosome; mice; derived mir; mir 130a ... See more keywords
Muscle-derived miR-126 regulates TDP-43 axonal local synthesis and NMJ integrity in ALS models
Sign Up to like & getrecommendations! Published in 2025 at "Nature Neuroscience"
DOI: 10.1038/s41593-025-02062-6
Abstract: Amyotrophic lateral sclerosis (ALS) is characterized by neuromuscular junction (NMJ) disruption and neurodegeneration. Recent findings highlight a pivotal role for TAR DNA-binding protein 43 (TDP-43) in forming axonal pathological condensates and facilitating NMJ disruption through… read more here.
Keywords: local synthesis; mir 126; synthesis; muscle derived ... See more keywords
T cell exosome-derived miR-142-3p impairs glandular cell function in Sjögren's syndrome.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.133497
Abstract: Sjögren's syndrome (SS) is a systemic autoimmune disease that mainly affects exocrine salivary and lacrimal glands. Local inflammation in the glands is thought to trigger glandular dysfunction and symptoms of dryness. However, the mechanisms underlying… read more here.
Keywords: gren syndrome; mir 142; cell exosome; derived mir ... See more keywords
Exosomes derived from mir-337-3p over-expressing tendon stem cells protect against apoptosis of tenocytes via targeting caspase3
Sign Up to like & getrecommendations! Published in 2024 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-024-07691-9
Abstract: Background Tendons are important dense fibrous structures connecting muscle to bone, and tendon stem cells (TDSCs) affect their repair and regeneration. The role of TDSC-derived exosomes (TDSC-Exos) is still being unexplored; therefore, this study aimed… read more here.
Keywords: tendon stem; mir 337; stem cells; apoptosis tenocytes ... See more keywords
Platelet-derived miR-142-3p induces apoptosis of endothelial cells in hypertension.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2017.63.4.1
Abstract: The dysfunction of endothelial cells (ECs) plays crucial roles in vascular remodeling during hypertension. Researches suggested that ECs are regulated by the circulating platelets in vivo, which may participate in abnormal EC apoptosis in hypertension.… read more here.
Keywords: mir 142; endothelial cells; hypertension; derived mir ... See more keywords
Glomerular Endothelial Cell-Derived microRNA-192 Regulates Nephronectin Expression in Idiopathic Membranous Glomerulonephritis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2020121699
Abstract: BACKGROUND Autoantibodies binding to podocyte antigens cause idiopathic membranous glomerulonephritis (iMGN). However, it remains elusive how autoantibodies reach the subepithelial space because the glomerular filtration barrier (GFB) is size selective and almost impermeable for antibodies.… read more here.
Keywords: derived mir; glomerular endothelial; podocyte; membranous glomerulonephritis ... See more keywords
Effect of exosomes derived from mir-126-modified mesenchymal stem cells on the repair process of spinal cord injury in rats.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202004_20975
Abstract: The article "Effect of exosomes derived from mir-126-modified mesenchymal stem cells on the repair process of spinal cord injury in rats, by B. Yuan, S. Pan, Y.-Q. Dong, W.-W. Zhang, X.-D. He, published in Eur… read more here.
Keywords: 126 modified; modified mesenchymal; mir 126; exosomes derived ... See more keywords
Exosomes derived from miR-140-5p-overexpressing human synovial mesenchymal stem cells enhance cartilage tissue regeneration and prevent osteoarthritis of the knee in a rat model
Sign Up to like & getrecommendations! Published in 2017 at "Theranostics"
DOI: 10.7150/thno.17133
Abstract: OBJECTIVES: Osteoarthritis (OA) is the most common joint disease throughout the world. Exosomes derived from miR-140-5p-overexpressing synovial mesenchymal stem cells (SMSC-140s) may be effective in treating OA. We hypothesized that exosomes derived from SMSC-140 (SMSC-140-Exos)… read more here.
Keywords: exosomes derived; 140 exos; smsc 140; derived mir ... See more keywords