Abstract 448: Computational discovery and experimental validation of splicing-derived neoantigens
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-448
Abstract: RNA splicing is a central step in the regulation of gene expression, leading to the accurate assembly of viable mRNA isoforms. Errors in the splicing process are common in cancer and lead to the production… read more here.
Keywords: tumor specific; validation; discovery; derived neoantigens ... See more keywords
Mutation-Derived Neoantigens for Cancer Immunotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.01856
Abstract: Mutation-derived neoantigens distinguish tumor from normal cells. T cells can sense the HLA-presented mutations, recognize tumor cells as non-self and destroy them. Therapeutically, immunotherapy antibodies can increase the virulence of the immune system by increasing… read more here.
Keywords: mutation derived; derived neoantigens; mutated proteins; neoantigens cancer ... See more keywords