Patient‐derived organoid models help define personalized management of gastrointestinal cancer
Sign Up to like & getrecommendations! Published in 2018 at "British Journal of Surgery"
DOI: 10.1002/bjs.10726
Abstract: The prognosis of patients with different gastrointestinal cancers varies widely. Despite advances in treatment strategies, such as extensive resections and the addition of new drugs to chemotherapy regimens, conventional treatment strategies have failed to improve… read more here.
Keywords: organoid models; models help; cancer; derived organoid ... See more keywords
Testing Susceptibility of Patient-Derived Organoid Cultures to Therapies: Pharmacotyping.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7847-2_19
Abstract: Increasingly, patient models of disease are being utilized to facilitate precision medicine approaches through molecular characterization or direct chemotherapeutic testing. Organoids, 3-dimensional (3D) cultures of neoplastic cells derived from primary tumor specimens, represent an ideal… read more here.
Keywords: susceptibility patient; organoid cultures; protocol; testing susceptibility ... See more keywords
Patient-derived Organoid Pharmacotyping is a Clinically Tractable Strategy for Precision Medicine in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Surgery"
DOI: 10.1097/sla.0000000000004200
Abstract: Supplemental Digital Content is available in the text Objective: PDAC patients who undergo surgical resection and receive effective chemotherapy have the best chance of long-term survival. Unfortunately, we lack predictive biomarkers to guide optimal systemic… read more here.
Keywords: medicine; precision medicine; patient derived; derived organoid ... See more keywords
Abstract 178: Establishment of patient-derived organoid of breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-178
Abstract: A patient-derived organoid (PDO) is an in vitro three-dimensional model which shows similar features in phenotypic and genetic aspects with primary tissue from patients. PDOs are useful for preclinical studies including drug sensitivity tests of… read more here.
Keywords: patient derived; breast cancer; cancer; derived organoid ... See more keywords
Abstract 189: Developing a patient-derived organoid biobank, suitable for large scale drug screenings
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-189
Abstract: Conventional models for preclinical drug screening offer poor predictive value for patient response, causing high attrition rates of new agents in the clinic. HUB’s proprietary Patient-Derived Organoid (PDO) Technology enables long-term expansion of primary patient… read more here.
Keywords: derived organoid; patient; patient derived; drug ... See more keywords
Abstract 5776: Advancing a screening platform with panels of patient-derived organoid models for drug discovery and development
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5776
Abstract: High-throughput screening (HTS) offers the potential to rapidly evaluate the activities of anticancer single agents and combinations in many types of cell-based tumor models; however, successful translation of the findings to patients requires tumor models… read more here.
Keywords: oncology; organoid models; derived organoid; patient derived ... See more keywords
Abstract A16: Patient-derived organoid-based models for endometrial cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.camodels2020-a16
Abstract: Introduction: Comprehensive profiling of tumors using omics technologies has improved our understanding of the molecular landscape of endometrial cancer (EC), building the foundation for precision medicine. However, targeted therapies that show promise in preclinical research… read more here.
Keywords: endometrial cancer; cancer; organoid based; derived organoid ... See more keywords
A pancreas tumor derived organoid study: from drug screen to precision medicine
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Cell International"
DOI: 10.1186/s12935-021-02044-1
Abstract: Pancreatic ductal adenocarcinoma (PDAC) one of the deadliest malignant tumor. Despite considerable progress in pancreatic cancer treatment in the past 10 years, PDAC mortality has shown no appreciable change, and systemic therapies for PDAC generally lack… read more here.
Keywords: medicine; pancreas tumor; tumor derived; organoid study ... See more keywords