Bioprinting of Patient-Derived Organoids for Predicting Cancer Therapy Responses.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202102784
Abstract: Cancer models. This article is protected by copyright. All rights reserved. read more here.
Keywords: cancer; predicting cancer; organoids predicting; derived organoids ... See more keywords
CRISPR/Cas9 Screen in Gastric Cancer Patient-Derived Organoids Reveals KDM1A-NDRG1 Axis as a Targetable Vulnerability.
Sign Up to like & getrecommendations! Published in 2023 at "Small methods"
DOI: 10.1002/smtd.202201605
Abstract: Viability CRISPR screens have proven indispensable in parsing genome function. However, their application in new, more physiologically relevant culturing systems like patient‐derived organoids (PDOs) has been much slower. To probe epigenetic contribution to gastric cancer… read more here.
Keywords: crispr; screen; derived organoids; patient derived ... See more keywords
Patient-Derived Organoids from Human Bile: An In Vitro Method to Study Cholangiopathies.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9420-5_24
Abstract: Cholangiopathies, including primary sclerosing cholangitis, are a group of heterogeneous diseases characterized by inflammation and fibrosis of the intrahepatic and extrahepatic bile duct epithelium. Studies, especially of primary sclerosing cholangitis, have been hampered by the… read more here.
Keywords: derived organoids; method; study; primary sclerosing ... See more keywords
The role of physical cues in the development of stem cell-derived organoids
Sign Up to like & getrecommendations! Published in 2021 at "European Biophysics Journal"
DOI: 10.1007/s00249-021-01551-3
Abstract: Organoids are a novel three-dimensional stem cells’ culture system that allows the in vitro recapitulation of organs/tissues structure complexity. Pluripotent and adult stem cells are included in a peculiar microenvironment consisting of a supporting structure… read more here.
Keywords: role; stem cell; derived organoids; stem ... See more keywords
Developing patient-derived organoids to predict PARP inhibitor response and explore resistance overcoming strategies in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.1016/j.phrs.2022.106232
Abstract: With the common use of poly ADP-ribose polymerase inhibitors (PARPi) for the man-agement of epithelial ovarian cancer (EOC) across the treatment life cycle, there is a critical need for the development of functional tests, as… read more here.
Keywords: response; derived organoids; ovarian cancer; resistance ... See more keywords
Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24746-w
Abstract: Human pluripotent stem cell (hPSC)-derived organoids and cells have similar characteristics to human organs and tissues. Thus, in vitro human organoids and cells serve as a superior alternative to conventional cell lines and animal models… read more here.
Keywords: human pluripotent; derived organoids; similarity; organoids cells ... See more keywords
O4: A NOVEL BOWEL DISEASE MODEL: PHENOTYPIC DIVERSITY OF CONTROL VS FAP ORGANOIDS
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Surgery"
DOI: 10.1093/bjs/znab117.004
Abstract: The lifetime risk of colorectal cancer in familial adenomatous polyposis (FAP) approaches 100%. In patients who have undergone prophylactic colectomy, duodenal cancer is 100-300 times more common than in the general population, and an important… read more here.
Keywords: novel bowel; derived organoids; model; disease ... See more keywords
Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Cell Biology"
DOI: 10.1093/jmcb/mjaa031
Abstract: Abstract Recent advances in development of protocols for directed differentiation from human pluripotent stem cells (hPSCs) to defined lineages, in combination with 3D organoid technology, have facilitated the generation of various endoderm-derived organoids for in… read more here.
Keywords: human pluripotent; derived organoids; pluripotent stem; organ development ... See more keywords
Integration of human inspection and artificial intelligence‐based morphological typing of patient‐derived organoids reveals interpatient heterogeneity of colorectal cancer
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DOI: 10.1111/cas.15396
Abstract: Colorectal cancer (CRC) is a heterogenous disease, and patients have differences in therapeutic response. However, the mechanisms underlying interpatient heterogeneity in the response to chemotherapeutic agents remain to be elucidated, and molecular tumor characteristics are… read more here.
Keywords: interpatient heterogeneity; derived organoids; colorectal cancer; patient derived ... See more keywords
Recapitulating hepatitis E virus–host interactions and facilitating antiviral drug discovery in human liver–derived organoids
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj5908
Abstract: Hepatotropic viruses naturally have narrow host and tissue tropisms, challenging the development of robust experimental models. The advent of organoid technology provides a unique opportunity for moving the field forward. Here, we demonstrate that three-dimensional… read more here.
Keywords: derived organoids; liver derived; hev; human liver ... See more keywords
Abstract 161: Patient-derived organoids (PDOs) hub of National Cancer Center, Korea: pre-clinical model for drug screening
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-161
Abstract: Purpose Cancer is one of the leading causes of death worldwide. Patient-derived tumor cells can serve as a powerful resource for studying pathophysiologic mechanisms and developing robust strategies for precision medicine. To address this problem,… read more here.
Keywords: cancer; derived organoids; pdos hub; patient derived ... See more keywords