MEK inhibitors cobimetinib and trametinib, regressed a gemcitabine-resistant pancreatic-cancer patient-derived orthotopic xenograft (PDOX)
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DOI: 10.18632/oncotarget.17667
Abstract: A pancreatic ductal adenocarcinoma (PDAC), obtained from a patient, was grown orthotopically in the pancreatic tail of nude mice to establish a patient-derived orthotopic (PDOX) model. Seven weeks after implantation, PDOX nude mice were divided… read more here.
Keywords: consecutive days; week weeks; mek inhibitors; pdox ... See more keywords
Recombinant methioninase combined with doxorubicin (DOX) regresses a DOX-resistant synovial sarcoma in a patient-derived orthotopic xenograft (PDOX) mouse model
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DOI: 10.18632/oncotarget.24996
Abstract: Synovial sarcoma (SS) is a recalcitrant subgroup of soft tissue sarcoma (STS). A tumor from a patient with high grade SS from a lower extremity was grown orthotopically in the right biceps femoris muscle of… read more here.
Keywords: sarcoma; dox; orthotopic xenograft; synovial sarcoma ... See more keywords
Establishment of Patient-derived Orthotopic Xenografts (PDX) as Models for Pancreatic Ductal Adenocarcinoma
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DOI: 10.21873/invivo.12809
Abstract: Background/Aim: Pancreatic cancer (PC) is one of the leading causes of cancer-related death. The purpose of the present study was to establish a patient-derived orthotopic xenograft model (PDOX) for pancreatic ductal adenocarcinoma (PDAC), thus providing… read more here.
Keywords: derived orthotopic; pancreatic ductal; ductal adenocarcinoma; patient derived ... See more keywords
In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma
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DOI: 10.3389/fonc.2023.1123492
Abstract: Introduction Ependymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent decades, with 10-year survival rates stagnating at just 67% for children aged… read more here.
Keywords: derived orthotopic; loss; patient; patient derived ... See more keywords
TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model
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DOI: 10.3390/ijms232012476
Abstract: Diffuse intrinsic pontine gliomas (DIPG), the first cause of cerebral pediatric cancer death, will greatly benefit from specific and non-invasive biomarkers for patient follow-up and monitoring of drug efficacy. Since biopsies are challenging for brain… read more here.
Keywords: intrinsic pontine; non invasive; derived orthotopic; patient derived ... See more keywords