Functional Beta Cell Mass from Device-Encapsulated hESC-Derived Pancreatic Endoderm Achieving Metabolic Control
Sign Up to like & getrecommendations! Published in 2018 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2018.01.040
Abstract: Summary Human stem cells represent a potential source for implants that replace the depleted functional beta cell mass (FBM) in diabetes patients. Human embryonic stem cell-derived pancreatic endoderm (hES-PE) can generate implants with glucose-responsive beta… read more here.
Keywords: functional beta; cell mass; beta; beta cell ... See more keywords
Abstract 173: Genomic characterization of patient-derived pancreatic cancer organoids
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-173
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer death with few effective therapies. Patient-derived organoids (PDOs) are a 3-D culture model that allow primary tumour cells to propagate, and have gained considerable traction… read more here.
Keywords: derived pancreatic; genomic characterization; characterization patient; patient ... See more keywords
Comparison of Omentum and Subcutis as Implant Sites for Device-Encapsulated Human iPSC-Derived Pancreatic Endoderm in Nude Rats
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DOI: 10.1177/09636897231167323
Abstract: Subcutaneous implants of device-encapsulated stem cell–derived pancreatic endoderm (PE) can establish a functional beta cell mass (FBM) with metabolic control in immune-compromised mice. In a study with human-induced pluripotent stem cell-PE, this outcome was favored… read more here.
Keywords: cell; beta; derived pancreatic; nude rats ... See more keywords
Posttransplant Characterization of Long-term Functional hESC-Derived Pancreatic Endoderm Grafts
Sign Up to like & getrecommendations! Published in 2018 at "Diabetes"
DOI: 10.2337/db18-0788
Abstract: The paucity of human donors limits broadened application of β-cell replacement therapy. Insulin-producing cells derived from human embryonic stem cells (hESCs) have recently been investigated clinically as a feasible surrogate to primary tissue. Herein, we… read more here.
Keywords: long term; posttransplant characterization; pancreatic endoderm; hesc derived ... See more keywords