Unlocking Natural Potential: Antibody‐Drug Conjugates With Naturally Derived Payloads for Cancer Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Phytotherapy Research"
DOI: 10.1002/ptr.8407
Abstract: Natural compound‐derived chemotherapies remain central to cancer treatment, however, they often cause off‐target side effects that negatively impact patients' quality of life. In contrast, antibody‐drug conjugates (ADCs) combine cytotoxic payloads with antibodies to specifically target… read more here.
Keywords: naturally derived; cancer; antibody drug; derived payloads ... See more keywords
Combretastatin A4-derived payloads for antibody-drug conjugates.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113355
Abstract: We describe the use of natural product combretastatin A4 (CA4) as a versatile new payload for the construction of antibody-drug conjugates (ADCs). Cetuximab conjugates consisting of CA4 derivatives were site-specially prepared by disulfide re-bridging approach… read more here.
Keywords: drug conjugates; derived payloads; combretastatin derived; antibody drug ... See more keywords