Structure‐guided stabilization of pathogen‐derived peptide‐HLA‐E complexes using non‐natural amino acids conserves native TCR recognition
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149745
Abstract: The nonpolymorphic class Ib molecule, HLA‐E, primarily presents peptides from HLA class Ia leader peptides, providing an inhibitory signal to NK cells via CD94/NKG2 interactions. read more here.
Keywords: derived peptide; stabilization pathogen; peptide hla; pathogen derived ... See more keywords
Short- and long-term antihypertensive effect of egg protein-derived peptide QIGLF.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.7762
Abstract: BACKGROUND The present study aimed to investigate the in vivo antihypertensive effect on spontaneously hypertensive rats (SHRs) induced by egg protein-derived peptide QIGLF, which has been previously characterized in vitro as a potent angiotensin-converting enzyme… read more here.
Keywords: protein derived; peptide qiglf; antihypertensive effect; effect ... See more keywords
A SUMO1-derived peptide targeting SUMO-interacting motif inhibits α-synuclein aggregation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.12.010
Abstract: The accumulation of α-synuclein amyloid fibrils in the brain is linked to Parkinson's disease and other synucleinopathies. The intermediate species in the early aggregation phase of α-synuclein are involved in the emergence of amyloid toxicity… read more here.
Keywords: synuclein aggregation; aggregation; sumo1; sumo1 derived ... See more keywords
Improved in vitro corneal delivery of a thrombospondin-1-derived peptide using a liposomal formulation.
Sign Up to like & getrecommendations! Published in 2018 at "Experimental eye research"
DOI: 10.1016/j.exer.2017.12.002
Abstract: Peptide delivery to and through ocular sites is a growing field of research interest. However, several barriers restrict the permeation and bioavailability of these molecules to target tissues. The main pharmacological barriers of topical administration… read more here.
Keywords: corneal; delivery; formulation; thrombospondin derived ... See more keywords
Eradication of methicillin resistant S. aureus from human skin by the novel LL-37-derived peptide P10 in four pharmaceutical ointments.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2019.07.014
Abstract: Skin bacterial colonization/infections are frequent causes of morbidity in patients with chronic wounds and allergic/inflammatory skin diseases. This study aimed to develop a novel approach to eradicate methicillin-resistant Staphylococcus aureus (MRSA), further referred to as… read more here.
Keywords: novel derived; human skin; methicillin resistant; hypromellose gel ... See more keywords
Small p53 derived peptide suitable for robust nanobodies dimerization.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of immunological methods"
DOI: 10.1016/j.jim.2021.113144
Abstract: Bivalent VHHs have been shown to display better functional affinity compared with their monovalent counterparts. Bivalency can be achieved either by inserting a hinge region between both VHHs units or by using modules that lead… read more here.
Keywords: dimerization; p53 derived; small p53; peptide suitable ... See more keywords
The semenogelin I-derived peptide SgI-52 in seminal plasma participates in sperm selection and clearance by macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Peptides"
DOI: 10.1016/j.peptides.2022.170799
Abstract: BACKGROUND Macrophages can phagocytose sperm, especially damaged spermatozoa, in the female genital tract. The semenogelin I-derived peptide SgI-52 in seminal plasma exhibits seminal plasma motility inhibitor (SPMI) activity and can inhibit sperm motility. This raises… read more here.
Keywords: peptide sgi; semenogelin derived; seminal plasma; sgi seminal ... See more keywords
Effects of cathelicidin-derived peptide from reptiles on lipopolysaccharide-induced intestinal inflammation in weaned piglets.
Sign Up to like & getrecommendations! Published in 2017 at "Veterinary immunology and immunopathology"
DOI: 10.1016/j.vetimm.2017.09.005
Abstract: Cathelicidins are the largest family of antimicrobial peptides. C-BF, which is short for Cathelicidin-Bungarus Fasciatus, was isolated from snake venom. C-BF was found to be the most potential substitutes for antibiotics. In this study, we… read more here.
Keywords: induced intestinal; effects cathelicidin; lps lps; cathelicidin derived ... See more keywords
Walnut-Derived Peptide Enhances Mitophagy via JNK-Mediated PINK1 Activation to Reduce Oxidative Stress in HT-22 Cells.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c00005
Abstract: Mitophagy has a neuroprotective effect on reactive oxygen species (ROS)-induced neurodegenerative diseases. The walnut-derived polypeptide (TW-7) has antioxidant activity and protects nerves by promoting autophagy. However, its action mechanism against oxidative stress through mitophagy remains… read more here.
Keywords: stress; derived peptide; via jnk; walnut derived ... See more keywords
Exploring the Limits of Cyanobactin Macrocyclase PatGmac: Cyclization of PawS-Derived Peptide Sunflower Trypsin Inhibitor-1 and Cyclotide Kalata B1
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Natural Products"
DOI: 10.1021/acs.jnatprod.2c01158
Abstract: The subtilisin-like macrocyclase PatGmac is produced by the marine cyanobacterium Prochloron didemni. This enzyme is involved in the last step of the biosynthesis of patellamides, a cyanobactin type of ribosomally expressed and post-translationally modified cyclic… read more here.
Keywords: macrocyclase patgmac; derived peptide; paws derived; patgmac cyclization ... See more keywords
Novel Antiamoebic Tyrocidine-Derived Peptide against Brain-Eating Amoebae
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c01614
Abstract: Acanthamoeba castellanii (A. castellanii) can cause Acanthamoeba keratitis, a sight-threatening infection, as well as a fatal brain infection termed granulomatous amoebic encephalitis, mostly in immunocompromised individuals. In contrast, Naegleria fowleri (N. fowleri) causes a deadly… read more here.
Keywords: castellanii fowleri; castellanii; tyrocidine derived; derived peptide ... See more keywords