Reconstitution of an Anti‐HER2 Antibody Paratope by Grafting Dual CDR‐Derived Peptides onto a Small Protein Scaffold
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology Journal"
DOI: 10.1002/biot.202000078
Abstract: Target‐binding small proteins are promising alternatives to conventional monoclonal antibodies (mAbs), offering advantages in terms of tissue penetration and manufacturing costs. Recently, a design strategy to create small proteins called fluctuation‐regulated affinity proteins (FLAPs) consisting… read more here.
Keywords: protein scaffold; dual cdr; cdr derived; cdr ... See more keywords
PTHrP‐Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3007
Abstract: There is an unmet need to understand the mechanisms underlying skeletal deterioration in diabetes mellitus (DM) and to develop therapeutic approaches to treat bone fragility in diabetic patients. We demonstrate herein that mice with type… read more here.
Keywords: pthrp derived; bone; mice; diabetic mice ... See more keywords
Nanoencapsulation Of Casein-Derived Peptides Within Electrospun Nanofibres.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11509
Abstract: BACKGROUND Bioactive peptides derived from milk proteins are recognized as functional foods, but their consumption is limited by undesirable or bitter flavour, poor stability and low bioavailability. Electrospinning is a versatile process for encapsulation of… read more here.
Keywords: milk; peptides loaded; casein derived; nanoencapsulation casein ... See more keywords
Hyperglucosylated adhesin‐derived peptides as antigenic probes in multiple sclerosis: Structure optimization and immunological evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Peptide Science"
DOI: 10.1002/psc.3281
Abstract: Peptides mimicking antigenic epitopes targeted by antibodies can be powerful tools to be used as antigen surrogates for the specific diagnosis and treatment of autoimmune diseases. Obtaining structural insights about the nature of peptide–antibody interaction… read more here.
Keywords: sclerosis; glc; multiple sclerosis; adhesin derived ... See more keywords
Functional properties of ovotransferrin from chicken egg white and its derived peptides: a review
Sign Up to like & getrecommendations! Published in 2021 at "Food Science and Biotechnology"
DOI: 10.1007/s10068-021-00901-3
Abstract: With emerging trends in the food and pharmaceutical industries, potential applications of egg-derived bioactive compounds were recognized. Ovotransferrin is a major egg white functional protein responsible for multiple bioactivities. The objectives of this review are… read more here.
Keywords: functional properties; derived peptides; properties ovotransferrin; egg white ... See more keywords
In Silico Derived Peptides for Inhibiting the Toxin–Antitoxin Systems of Mycobacterium tuberculosis: Basis for Developing Peptide-Based Therapeutics
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Peptide Research and Therapeutics"
DOI: 10.1007/s10989-018-9792-8
Abstract: Toxin–antitoxin (TA) systems of Mycobacterium tuberculosis (Mtb) is a prerequisite for the bacterium to survive in extreme conditions. Antimicrobial peptides inhibiting the formation of these complexes provide a novel strategy for TB drug discovery process.… read more here.
Keywords: antitoxin systems; systems mycobacterium; derived peptides; silico derived ... See more keywords
Neuropeptide VGF-Derived Peptide LQEQ-19 has Neuroprotective Effects in an In Vitro Model of Amyotrophic Lateral Sclerosis
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemical Research"
DOI: 10.1007/s11064-019-02725-4
Abstract: Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease caused by the loss of upper and lower motor neurons resulting in muscle weakness and paralysis. Recently, VGF, a neuropeptide that is a precursor of bioactive… read more here.
Keywords: vgf derived; neuroprotective effects; amyotrophic lateral; derived peptides ... See more keywords
Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Physiology and Biochemistry"
DOI: 10.1007/s13105-020-00755-z
Abstract: Elastin, the major protein of the extracellular matrix, is specially found in cardiovascular tissues and contributing to 30–50% of the dry weight of blood vessels. Elastin regulates cell signalling pathways involved in morphogenesis, injury response… read more here.
Keywords: elastin derived; lac cer; adipocyte differentiation; lactosylceramide ... See more keywords
Enhancing Schwann cell migration using concentration gradients of laminin-derived peptides.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119335
Abstract: Neuroregeneration following peripheral nerve injury is largely mediated by Schwann cells (SC), the principal glial cell that supports neurons in the peripheral nervous system. Axonal regeneration in vivo is limited by the extent of SC… read more here.
Keywords: laminin derived; migration; concentration gradients; concentration ... See more keywords
Supramolecular Organization of Apolipoprotein-A-I-Derived Peptides within Disc-like Arrangements.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.06.026
Abstract: Apolipoprotein A-I is the major protein component of high-density lipoproteins and fulfils important functions in lipid metabolism. Its structure consists of a chain of tandem domains of amphipathic helices. Using this protein as a template… read more here.
Keywords: supramolecular organization; disc like; organization apolipoprotein; peptides within ... See more keywords
The islet’s bridesmaid becomes the bride: Proglucagon-derived peptides deliver transformative therapies
Sign Up to like & getrecommendations! Published in 2021 at "Cell"
DOI: 10.1016/j.cell.2021.03.019
Abstract: The 2021 Gairdner Prize is awarded to Daniel Drucker, Joel Habener, and Jens Juul Holst for the discovery of novel peptides encoded in the proglucagon sequence and the establishment of their physiological roles. These discoveries… read more here.
Keywords: proglucagon derived; islet bridesmaid; bride proglucagon; bridesmaid becomes ... See more keywords