Identifying Multiomic Signatures of X‐Linked Retinoschisis‐Derived Retinal Organoids and Mice Harboring Patient‐Specific Mutation Using Spatiotemporal Single‐Cell Transcriptomics
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202405818
Abstract: X‐linked retinoschisis (XLRS) is an inherited retinal disorder with severe retinoschisis and visual impairments. Multiomics approaches integrate single‐cell RNA‐sequencing (scRNA‐seq) and spatiotemporal transcriptomics (ST) offering potential for dissecting transcriptional networks and revealing cell‐cell interactions involved… read more here.
Keywords: mice; derived retinal; retinal organoids; cell ... See more keywords
Development of a protocol for maintaining viability while shipping organoid‐derived retinal tissue
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Tissue Engineering and Regenerative Medicine"
DOI: 10.1002/term.2997
Abstract: Retinal organoid technology enables generation of an inexhaustible supply of three‐dimensional retinal tissue from human pluripotent stem cells (hPSCs) for regenerative medicine applications. The high similarity of organoid‐derived retinal tissue and transplantable human fetal retina… read more here.
Keywords: medicine; retinal tissue; organoid derived; tissue ... See more keywords
Survival and functionality of xeno‐free human embryonic stem cell–derived retinal pigment epithelial cells on polyester substrate after transplantation in rabbits
Sign Up to like & getrecommendations! Published in 2018 at "Acta Ophthalmologica"
DOI: 10.1111/aos.14004
Abstract: To study immunogenic properties of human embryonic stem cell–derived retinal pigment epithelium (hESC‐RPE) and to evaluate subretinal xenotransplantation of hESC‐RPE on porous polyethylene terephthalate (PET) in rabbits. read more here.
Keywords: cell derived; stem cell; retinal pigment; embryonic stem ... See more keywords
Characterization of Primary Cilia Formation in Human ESC-Derived Retinal Organoids
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/6494486
Abstract: Objectives Primary cilia are conserved organelles found in polarized mammalian cells that regulate neuronal growth, migration, and differentiation. Proper cilia formation is essential during eye development. Our previous reports found that both amacrine and retinal… read more here.
Keywords: day; cilia formation; derived retinal; retinal organoids ... See more keywords
Abstract 4139960: AI-Derived Retinal Vasculature Features Predict Cardiovascular Risk in Patients with Chronic Kidney Disease: Insights from the CRIC Study
Sign Up to like & getrecommendations! Published in 2024 at "Circulation"
DOI: 10.1161/circ.150.suppl_1.4139960
Abstract: Background: Chronic kidney disease (CKD) is associated with increased risk of cardiovascular disease (CVD) and mortality. Fundus imaging offers a non-invasive method for CVD risk stratification through insights into microvascular disease. Hypothesis: Artificial-intelligence (AI)-derived retinal… read more here.
Keywords: disease; derived retinal; risk; cvd risk ... See more keywords
Human iPSC-derived retinal organoids develop robust Alzheimer’s disease neuropathology
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2024.1340448
Abstract: Alzheimer’s disease (AD), characterized by memory loss and cognitive decline, affects nearly 50 million people worldwide. Amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) of phosphorylated Tau protein (pTau) are key histopathological features of… read more here.
Keywords: alzheimer disease; disease; derived retinal; human ipsc ... See more keywords
Expression of Endogenous Angiotensin-Converting Enzyme 2 in Human Induced Pluripotent Stem Cell-Derived Retinal Organoids
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22031320
Abstract: Angiotensin-converting enzyme 2 (ACE2) was identified as the main host cell receptor for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its subsequent infection. In some coronavirus disease 2019 (COVID-19) patients, it… read more here.
Keywords: angiotensin converting; converting enzyme; sars cov; retinal organoids ... See more keywords