RNF34 ablation promotes cerebrovascular remodeling and hypertension by increasing NADPH-derived ROS generation
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DOI: 10.1016/j.nbd.2021.105396
Abstract: Cerebrovascular remodeling is the most common cause of hypertension and stroke. Ubiquitin E3 ligase RING finger protein 34 (RNF34) is suggested to be associated with the development of multiple neurological diseases. However, the importance of… read more here.
Keywords: remodeling hypertension; rnf34; ros generation; derived ros ... See more keywords
Mitochondrial redox plays a critical role in the paradoxical effects of NAPDH oxidase-derived ROS on coronary endothelium
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DOI: 10.1093/cvr/cvw249
Abstract: Aims There are conflicting reports on the role of reactive oxygen species (ROS) i.e. beneficial vs. harmful, in vascular endothelium. Here, we aim to examine whether duration of exposure to ROS and/or subcellular ROS levels… read more here.
Keywords: endothelium; term; increase; derived ros ... See more keywords