Proteomic analysis of human iPSC-derived sensory neurons implicates cell stress and microtubule dynamics dysfunction in bortezomib-induced peripheral neurotoxicity
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DOI: 10.1016/j.expneurol.2020.113520
Abstract: The neurotoxic effects of the chemotherapeutic agent bortezomib on dorsal root ganglia sensory neurons are well documented, yet the mechanistic underpinnings that govern these cellular processes remain incompletely understood. In this study, system-wide proteomic changes… read more here.
Keywords: derived sensory; bortezomib; microtubule dynamics; sensory neurons ... See more keywords
The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell–derived sensory neurons of erythromelalgia patients
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DOI: 10.1097/j.pain.0000000000001511
Abstract: Supplemental Digital Content is Available in the Text. Human sodium channel NaV1.7 in induced pluripotent stem cell–derived sensory neurons sets the action potential threshold but does not support subthreshold depolarizations. read more here.
Keywords: derived sensory; cell derived; stem cell; pluripotent stem ... See more keywords
A Novel In Vitro Assay Using Human iPSC-Derived Sensory Neurons to Evaluate the Effects of External Chemicals on Neuronal Morphology: Possible Implications in the Prediction of Abnormal Skin Sensation
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DOI: 10.3390/ijms221910525
Abstract: Neuronal morphological changes in the epidermis are considered to be one of causes of abnormal skin sensations in dry skin-based skin diseases. The present study aimed to develop an in vitro model optimised for human… read more here.
Keywords: derived sensory; abnormal skin; skin; benzo pyrene ... See more keywords