On the pseudorandomness of quaternary sequences derived from sequences over $$\mathbb F_4$$F4
Sign Up to like & getrecommendations! Published in 2017 at "Periodica Mathematica Hungarica"
DOI: 10.1007/s10998-016-0143-2
Abstract: In analogy to the corresponding measures of pseudorandomness for quaternary sequences introduced by Mauduit and Sárközy (for m-ary sequences) we introduce the well-distribution measure and correlation measure of order k for sequences over $$\mathbb F_4$$F4.… read more here.
Keywords: quaternary sequences; sequences derived; sequences mathbb; derived sequences ... See more keywords
Synthetic Antibiotic Derived from Sequences Encrypted in a Protein from Human Plasma.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.1c04496
Abstract: Encrypted peptides have been recently found in the human proteome and represent a potential class of antibiotics. Here we report three peptides derived from the human apolipoprotein B (residues 887-922) that exhibited potent antimicrobial activity… read more here.
Keywords: derived sequences; synthetic antibiotic; antibiotic derived; sequences encrypted ... See more keywords
Redesigning an antibody H3 loop by virtual screening of a small library of human germline-derived sequences
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-00669-w
Abstract: The design of superior biologic therapeutics, including antibodies and engineered proteins, involves optimizing their specific ability to bind to disease-related molecular targets. Previously, we developed and applied the Assisted Design of Antibody and Protein Therapeutics… read more here.
Keywords: antibody; derived sequences; human germline; redesigning antibody ... See more keywords
Function and Constraint in Enhancer Sequences with Multiple Evolutionary Origins
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DOI: 10.1093/gbe/evac159
Abstract: Abstract Thousands of human gene regulatory enhancers are composed of sequences with multiple evolutionary origins. These evolutionarily “complex” enhancers consist of older “core” sequences and younger “derived” sequences. However, the functional relationship between the sequences… read more here.
Keywords: variation; sequences multiple; evolutionary origins; derived sequences ... See more keywords