Regulation of DNA‐PK activity promotes the progression of TNBC via enhancing the immunosuppressive function of myeloid‐derived suppressor cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5387
Abstract: DNA‐dependent protein kinase (DNA‐PK) is engaged in DNA damage repair and is significantly expressed in triple negative breast cancer (TNBC). Inhibiting DNA‐PK to reduce DNA damage repair provides a possibility of tumor treatment. NU7441, a… read more here.
Keywords: function; dna; myeloid derived; suppressor cells ... See more keywords
Phenotypically resembling myeloid derived suppressor cells are increased in children with HIV and exposed/infected with Mycobacterium tuberculosis
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201646658
Abstract: Increased disease susceptibility during early life has been linked to immune immaturity, regulatory T‐cell/TH2 immune biasing and hyporesponsiveness. The contribution of myeloid derived suppressor cells (MDSCs) remains uninvestigated. Here, we assessed peripheral MDSC in HIV‐infected… read more here.
Keywords: suppressor cells; derived suppressor; hiv; hiv exposed ... See more keywords
Human monocytic myeloid‐derived suppressor cells impair B‐cell phenotype and function in vitro
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201948240
Abstract: Myeloid‐derived suppressor cells (MDSCs) are key regulators of immunity that initially have been defined by their ability to potently suppress T‐cell responses. Recent studies collectively demonstrate that the suppressive activity of MDSCs is not limited… read more here.
Keywords: suppressor cells; derived suppressor; human monocytic; function ... See more keywords
Targeted deletion of HIF-1α in myeloid cells of neonatal mice: decreased accumulation of myeloid-derived suppressor cells and altered microbiome.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250144
Abstract: The newborn's immune system is faced with the challenge of having to learn quickly to fight off infectious agents, but tolerating the colonization of the body surfaces with commensals without reacting with an excessive inflammatory… read more here.
Keywords: myeloid derived; suppressor cells; hif; myeloid ... See more keywords
Differential gene expression profile in monocytic myeloid‐derived suppressor cells at maternal–fetal interface in a mouse model of spontaneous abortion
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DOI: 10.1002/jcp.27902
Abstract: Monocytic myeloid‐derived suppressor cells (MO‐MDSCs) play an important role in maintaining normal pregnancy. However, it is still not clear what kind of changes in MO‐MDSCs may lead to miscarriage, and which gene expression changes take… read more here.
Keywords: suppressor cells; derived suppressor; monocytic myeloid; gene expression ... See more keywords
HDAC11 regulates expression of C/EBPβ and immunosuppressive molecules in myeloid‐derived suppressor cells
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1a1119-606rrr
Abstract: Myeloid‐derived suppressor cells (MDSCs) constitute a heterogeneous population of immature myeloid cells derived from bone marrow and negatively regulate both innate and adaptive immunity in the tumor microenvironment. Previously we have demonstrated that MDSCs lacking… read more here.
Keywords: expression; myeloid derived; hdac11; immunosuppressive molecules ... See more keywords
Prophylactic DNA vaccine targeting Foxp3+ regulatory T cells depletes myeloid-derived suppressor cells and improves anti-melanoma immune responses in a murine model
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-2088-6
Abstract: Regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSC) are the two important and interactive immunosuppressive components of the tumor microenvironment that hamper anti-tumor immune responses. Therefore, targeting these two populations together might be beneficial… read more here.
Keywords: suppressor cells; derived suppressor; regulatory cells; vaccine ... See more keywords
The role of myeloid derived suppressor cells in mycosis fungoides
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DOI: 10.1007/s00262-018-2153-9
Abstract: We have read with interest the recent publication “Thera‐ peutic reduction of cell‐mediated immunosuppression in mycosis fungoides and Sézary syndrome” by Geskin et al. [1] and would like to comment on it based on our… read more here.
Keywords: derived suppressor; mycosis fungoides; mdsc; role ... See more keywords
Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02388-8
Abstract: Myeloid-derived suppressor cells (MDSC) are present in most cancer patients where they are significant contributors to the immune suppressive tumor microenvironment (TME). The TME is a hostile locale due to deficiencies in oxygen (hypoxia) and… read more here.
Keywords: hmgb1; suppressor cells; derived suppressor; tumor microenvironment ... See more keywords
Response to radiotherapy in pancreatic ductal adenocarcinoma is enhanced by inhibition of myeloid-derived suppressor cells using STAT3 anti-sense oligonucleotide
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02701-w
Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a heterogeneous tumor microenvironment (TME) comprised of myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages, neutrophils, regulatory T cells, and myofibroblasts. The precise mechanisms that regulate the composition of the TME and… read more here.
Keywords: derived suppressor; response; radiotherapy; pancreatic ductal ... See more keywords
Recent advances in myeloid-derived suppressor cell biology
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DOI: 10.1007/s11684-020-0797-2
Abstract: In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatory conditions has become a very active research area. Although the role of MDSCs in cancer is relatively well established, their… read more here.
Keywords: derived suppressor; biology; recent advances; advances myeloid ... See more keywords