The application of zebrafish patient‐derived xenograft tumor models in the development of antitumor agents
Sign Up to like & getrecommendations! Published in 2022 at "Medicinal Research Reviews"
DOI: 10.1002/med.21924
Abstract: The cost of antitumor drug development is enormous, yet the clinical outcomes are less than satisfactory. Therefore, it is of great importance to develop effective drug screening methods that enable accurate, rapid, and high‐throughput discovery… read more here.
Keywords: antitumor; tumor; patient derived; derived xenograft ... See more keywords
Guided bone regeneration simultaneous with implant placement using bovine-derived xenograft with and without liquid platelet-rich fibrin: a randomized controlled clinical trial.
Sign Up to like & getrecommendations! Published in 2021 at "Clinical oral investigations"
DOI: 10.1007/s00784-021-03987-5
Abstract: OBJECTIVE To assess augmentation success after guided bone regeneration (GBR) carried out simultaneously with implant placement using bovine-derived xenograft alone and in combination with liquid platelet-rich fibrin (liquid-PRF). METHODS This randomized controlled clinical trial was… read more here.
Keywords: bone; bovine derived; derived xenograft; implant placement ... See more keywords
Patient-derived xenograft models of neuroendocrine prostate cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.11.004
Abstract: In recent years, patient-derived xenografts (PDXs) have attracted much attention as clinically relevant models for basic and translational cancer research. PDXs retain the principal histopathological and molecular heterogeneity of their donor tumors and remain stable… read more here.
Keywords: xenograft models; prostate cancer; derived xenograft; neuroendocrine prostate ... See more keywords
Establishment and characterization of uterine sarcoma and carcinosarcoma patient-derived xenograft models.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.06.005
Abstract: OBJECTIVE Uterine sarcomas (US) and carcinosarcomas (CS) are rare, aggressive cancers. The lack of reliable preclinical models hampers the search for new treatment strategies and predictive biomarkers. To this end, we established and characterized US… read more here.
Keywords: uterine sarcoma; xenograft; sarcoma carcinosarcoma; derived xenograft ... See more keywords
Establishment and preclinical application of a patient-derived xenograft model for uterine cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2021.04.028
Abstract: BACKGROUND The patient-derived xenograft (PDX) model is a promising translational platform for duplicating the characteristics of primary tumors. Here, we established and characterized PDX models of uterine cancer to demonstrate their utility for preclinical drug… read more here.
Keywords: uterine cancer; derived xenograft; model; pdx ... See more keywords
Evaluation of EDB Fibronectin in Plasma, Patient-Derived Xenograft Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tumor Tissues Using Immunoaffinity LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.2c00182
Abstract: The fibronectin (FN) isoform including the extradomain B (EDB) segment (EDB + FN) is a promising tumor target and is highly expressed in some tumor types, such as breast, head, and neck cancer. To date,… read more here.
Keywords: plasma patient; formalin fixed; edb; patient derived ... See more keywords
Development and Characterization of a Spontaneously Metastatic Patient-Derived Xenograft Model of Human Prostate Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-35695-8
Abstract: Here we describe the establishment and characterization of an AR+, PSMA+, ERG+, PTEN−/−, CHD1+/− patient-derived xenograft (PDX) model termed ‘C5’, which has been developed from a 60 years old patient suffering from castration-resistant prostate cancer… read more here.
Keywords: prostate cancer; derived xenograft; model; mice ... See more keywords
Generation and application of patient-derived xenograft models in pancreatic cancer research
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000000524
Abstract: Abstract Objective: Pancreatic ductal adenocarcinoma cancer (PDAC) is one of the leading causes of cancer-related death worldwide. Hence, the development of effective anti-PDAC therapies is urgently required. Patient-derived xenograft (PDX) models are useful models for… read more here.
Keywords: pdx models; cancer; derived xenograft; patient derived ... See more keywords
Report of the use of patient‐derived xenograft models in the development of anticancer drugs in Japan
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Science"
DOI: 10.1111/cas.14564
Abstract: Abstract Cell line‐derived xenograft (CDX) models created by implanting cancer cell lines into immunodeficient mice have contributed largely to the development of cancer drug therapies. However, cell lines often lose their original biological characteristics through… read more here.
Keywords: pdx models; development anticancer; derived xenograft; anticancer drugs ... See more keywords
Correlation between Patient‐Derived Xenograft Modeling and Prognosis in Osteosarcoma
Sign Up to like & getrecommendations! Published in 2022 at "Orthopaedic Surgery"
DOI: 10.1111/os.13211
Abstract: To retrospectively analyze and compare the relationship between the success rate of patient‐derived xenograft (PDX) modeling of osteosarcoma and prognosis (3‐year overall survival rate and disease‐free survival rate) and incidence of lung metastasis. read more here.
Keywords: correlation patient; xenograft modeling; patient derived; derived xenograft ... See more keywords
PO-441 Characterisation of 3D patient-derived xenograft tumour microtissues for in vitro oncology drug development
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.952
Abstract: Introduction In vitro cell based drug testing tools have been widely used in drug discovery and early development to evaluate novel drug entities for further evaluation in preclinical in vivo models. However, the question on… read more here.
Keywords: drug; derived xenograft; tumour microtissues; oncology ... See more keywords