Contribution of keratinocytes to dermal fibrosis
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Rheumatology"
DOI: 10.1097/bor.0000000000000895
Abstract: Purpose of review The cellular pathogenesis of fibrotic disorders including systemic sclerosis (SSc) remains largely speculative. Currently, the altered function of endothelial cells and fibroblasts under the influence of an inappropriate immune response are considered… read more here.
Keywords: dermal fibrosis; rheumatology; contribution keratinocytes; ssc ... See more keywords
Secukinumab and metformin ameliorate dermal fibrosis by decreasing tissue interleukin‐17 levels in bleomycin‐induced dermal fibrosis
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Rheumatic Diseases"
DOI: 10.1111/1756-185x.14114
Abstract: Although the pathogenesis of systemic sclerosis is not exactly known, it is thought that immune activation has prominent roles in pathogenesis. Secukinumab is a monoclonal antibody against interleukin (IL)‐17A. Metformin, a widely used antidiabetic medication,… read more here.
Keywords: dermal fibrosis; fibrosis; induced dermal; tissue ... See more keywords
Simvastatin cream alleviates dermal fibrosis in a rabbit ear hypertrophic scar model
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DOI: 10.1111/jocd.15142
Abstract: Hypertrophic scars (HTS) result from injury to the skin and represent a clinical burden with limited treatment options. Previously, we demonstrated that statin drugs could attenuate HTS formation, but convenient topical delivery and retention of… read more here.
Keywords: dermal fibrosis; alleviates dermal; simvastatin cream; cream alleviates ... See more keywords
A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition
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DOI: 10.3390/genes10020075
Abstract: Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysregulation, vasculopathy, and organ fibrosis. Skin fibrosis causes high morbidity and impaired quality of life in affected individuals. Animal models do not fully… read more here.
Keywords: fibrosis; human skin; skin; model ... See more keywords