In Silico Prediction of Chemical Acute Dermal Toxicity Using Explainable Machine Learning Methods.
Sign Up to like & getrecommendations! Published in 2024 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.4c00012
Abstract: The research on acute dermal toxicity has consistently been a crucial component in assessing the potential risks of human exposure to active ingredients in pesticides and related plant protection products. However, it is difficult to… read more here.
Keywords: prediction; dermal toxicity; acute dermal; machine learning ... See more keywords
Cytotoxicity, Dermal Toxicity, and In Vivo Antifungal Effect of Griseofulvin-Loaded Vaterite Carriers Administered via Sonophoresis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.3c00084
Abstract: The search for novel therapeutic strategies to treat fungal diseases is of special importance nowadays given the emerging threat of drug resistance. Various particulate delivery systems are extensively being developing to enhance bioavailability, site-specific penetration,… read more here.
Keywords: cytotoxicity dermal; vivo; effect; dermal toxicity ... See more keywords
Exploring the dermal safety of green-synthesized Ag–TiO2 nanocomposites for topical applications
Sign Up to like & getrecommendations! Published in 2025 at "RSC Advances"
DOI: 10.1039/d4ra08199d
Abstract: We investigated Ag–TiO2 nanocomposites (NCs) synthesized using leaf extracts of Azadirachta indica and Mangifera indica for topical applications. The Ag–TiO2 NCs were first characterized by their spherical shapes, with sizes ranging from 20–26 nm to… read more here.
Keywords: dermal toxicity; topical applications; tio2; dermal safety ... See more keywords
Subacute dermal toxicity study of bensulfuron-methyl in Sprague-Dawley rats
Sign Up to like & getrecommendations! Published in 2022 at "Cutaneous and Ocular Toxicology"
DOI: 10.1080/15569527.2022.2077750
Abstract: Abstract Background: Bensulfuron-methyl has recently attracted attention given its widespread use as an herbicide in crops, especially its transdermal safety. However, no dermal toxicity study of this pesticide to mammals has been reported. The present… read more here.
Keywords: bensulfuron methyl; dermal toxicity; toxicity study;
GraphADT: empowering interpretable predictions of acute dermal toxicity with multi-view graph pooling and structure remapping
Sign Up to like & getrecommendations! Published in 2024 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btae438
Abstract: Abstract Motivation Accurate prediction of acute dermal toxicity (ADT) is essential for the safe and effective development of contact drugs. Currently, graph neural networks, a form of deep learning technology, accurately model the structure of… read more here.
Keywords: view; structure; dermal toxicity; acute dermal ... See more keywords
Epidermal growth factor receptor (EGFR) inhibitor-induced dermal toxicity treated with topical application of a novel Staphylococcus epidermidis compound.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2025.43.16_suppl.tps12149
Abstract: TPS12149 Background: Agents targeting the EGFR-mediated signaling pathway are used for the treatment of advanced lung, pancreatic, colorectal, and head and neck cancers. Significant dermal toxicities, occurring in up to 90% of patients treated with… read more here.
Keywords: dermal toxicity; atr04 484; growth; application ... See more keywords
Semi-Correlations for the Simulation of Dermal Toxicity
Sign Up to like & getrecommendations! Published in 2025 at "Toxics"
DOI: 10.3390/toxics13040235
Abstract: The skin is the primary pathway for harmful substances to enter the body and a susceptible target organ, making compound-induced acute dermal toxicity a significant health risk. In this work, the possibility of modelling dermal… read more here.
Keywords: semi correlations; correlations simulation; dermal toxicity; simulation dermal ... See more keywords