Clinical and pathophysiological delineation of musculocontractural Ehlers—Danlos syndrome caused by dermatan sulfate epimerase deficiency (mcEDS‐DSE): A detailed and comprehensive glycobiological and pathological investigation in a novel patient
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24437
Abstract: Musculocontractural Ehlers–Danlos syndrome caused by dermatan sulfate epimerase deficiency (mcEDS‐DSE) is a rare connective tissue disorder. This is the first report describing the detailed and comprehensive clinical and pathophysiological features of mcEDS‐DSE. The patient, with… read more here.
Keywords: danlos syndrome; dermatan sulfate; ehlers danlos; mceds dse ... See more keywords
Targeted anti-inflammatory peptide delivery in injured endothelial cells using dermatan sulfate/chitosan nanomaterials.
Sign Up to like & getrecommendations! Published in 2020 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2019.115610
Abstract: This work describes a novel delivery system for targeting egg-derived anti-inflammatory tripeptide Ile-Arg-Trp (IRW) to endothelial cells. The nanomedicine is synthesized by a simple and reproducible ionotropic gelification method that results in the efficient loading… read more here.
Keywords: anti inflammatory; sulfate; sulfate chitosan; dermatan sulfate ... See more keywords
Sequencing the Dermatan Sulfate Chain of Decorin.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b10164
Abstract: Glycomics represents one of the last frontiers and most challenging in omic analysis. Glycosylation occurs in the endoplasmic reticulum and the Golgi organelle and its control is neither well-understood nor predictable based on proteomic or… read more here.
Keywords: chain; sulfate; dermatan sulfate; chain decorin ... See more keywords
Quantitative 2D 1 H, 13 C HSQC NMR Spectroscopy for the Determination of Chondroitin Sulfate and Dermatan Sulfate Content in Danaparoid Sodium
Sign Up to like & getrecommendations! Published in 2022 at "Thrombosis and Haemostasis"
DOI: 10.1055/s-0043-1768225
Abstract: OBJECTIVE Danaparoid sodium is a biopolymeric complex drug composed of the most abundant heparan sulfate (HS) followed in descending order by dermatan sulfate (DS) and chondroitin sulfate (CS). This composite nature explains its peculiar antithrombotic… read more here.
Keywords: spectroscopy; chondroitin sulfate; dermatan sulfate; danaparoid sodium ... See more keywords
Co-immobilization of chitosan and dermatan sulfate from Raja montagui skin on polyethylene terephthalate surfaces: Characterization and antibiofilm activity
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Polymeric Materials and Polymeric Biomaterials"
DOI: 10.1080/00914037.2017.1320664
Abstract: ABSTRACT In this work, polyethylene terephthalate (PET) was chemically modified by covalent co-immobilization of two separate layers of bioactive polymers composed of chitosan and a new dermatan sulfate isolated from Raja montagui skin. The new… read more here.
Keywords: polyethylene terephthalate; sulfate; dermatan sulfate; montagui skin ... See more keywords
Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1010067
Abstract: Chondroitin/dermatan sulfate (CS/DS) proteoglycans are indispensable for animal development and homeostasis but the large number of enzymes involved in their biosynthesis have made CS/DS function a challenging problem to study genetically. In our study, we… read more here.
Keywords: development; biosynthesis; dermatan sulfate; csgalnact1a csgalnact2 ... See more keywords
Gene expression of the two developmentally regulated dermatan sulfate epimerases in the Xenopus embryo
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0191751
Abstract: Chondroitin sulfate (CS)/dermatan sulfate (DS) proteoglycans are abundant on the cell surface and in the extracellular matrix and have important functions in matrix structure, cell-matrix interaction and signaling. The DS epimerases 1 and 2, encoded… read more here.
Keywords: sulfate; dermatan sulfate; gene expression; expression ... See more keywords
Histories of Dermatan Sulfate Epimerase and Dermatan 4-O-Sulfotransferase from Discovery of Their Enzymes and Genes to Musculocontractural Ehlers-Danlos Syndrome
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14020509
Abstract: Dermatan sulfate (DS) and its proteoglycans are essential for the assembly of the extracellular matrix and cell signaling. Various transporters and biosynthetic enzymes for nucleotide sugars, glycosyltransferases, epimerase, and sulfotransferases, are involved in the biosynthesis… read more here.
Keywords: danlos syndrome; histories dermatan; sulfate epimerase; dermatan sulfate ... See more keywords
The Specific Role of Dermatan Sulfate as an Instructive Glycosaminoglycan in Tissue Development
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137485
Abstract: The crucial roles of dermatan sulfate (DS) have been demonstrated in tissue development of the cutis, blood vessels, and bone through construction of the extracellular matrix and cell signaling. Although DS classically exerts physiological functions… read more here.
Keywords: role; tissue development; dermatan sulfate; tissue ... See more keywords
Effects of Dermatan Sulfate from Marine Invertebrate Styela plicata in the Wound Healing Pathway: A Natural Resource Applied to Regenerative Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Marine Drugs"
DOI: 10.3390/md20110676
Abstract: Acute and chronic dermatological injuries need rapid tissue repair due to the susceptibility to infections. To effectively promote cutaneous wound recovery, it is essential to develop safe, low-cost, and affordable regenerative tools. Therefore, we aimed… read more here.
Keywords: marine invertebrate; styela plicata; wound healing; healing pathway ... See more keywords
Identification and Structural Characterization of Novel Chondroitin/Dermatan Sulfate Hexassacharide Domains in Human Decorin by Ion Mobility Tandem Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27186026
Abstract: Chondroitin sulfate (CS) and dermatan sulfate (DS) are found in nature linked to proteoglycans, most often as hybrid CS/DS chains. In the extracellular matrix, where they are highly expressed, CS/DS are involved in fundamental processes… read more here.
Keywords: mass spectrometry; chondroitin; dermatan sulfate; domains human ... See more keywords