Diethylstilbestrol, flutamide and their combination impaired the spermatogenesis of male adult zebrafish through disrupting HPG axis, meiosis and apoptosis.
Sign Up to like & getrecommendations! Published in 2017 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2017.02.013
Abstract: Both diethylstilbestrol (DES, an environmental estrogen) and flutamide (FLU, an anti-androgen) are found to impair spermatogenesis by disrupting hypothalamic-pituitary-gonadal (HPG) axis and altering androgen levels through different mechanisms/modes of action in fish with poorly understood… read more here.
Keywords: combination; apoptosis; des flu; hpg axis ... See more keywords