Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer’s Disease Transgenic Model
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2312-2
Abstract: ABSTRACTPurposeThe induction of autophagy has recently been explored as a promising therapeutic strategy to combat Alzheimer’s disease. Among many other factors, there is evidence that ceramides/dihydroceramides act as mediators of autophagy, although the exact mechanisms… read more here.
Keywords: desaturase inhibitors; desaturase; alzheimer disease; reduce amyloid ... See more keywords
Sodium Orthovanadate Changes Fatty Acid Composition and Increased Expression of Stearoyl-Coenzyme A Desaturase in THP-1 Macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Biological Trace Element Research"
DOI: 10.1007/s12011-019-01699-2
Abstract: Vanadium compounds are promising antidiabetic agents. In addition to regulating glucose metabolism, they also alter lipid metabolism. Due to the clear association between diabetes and atherosclerosis, the purpose of the present study was to assess… read more here.
Keywords: acid; expression; sodium orthovanadate; desaturase ... See more keywords
Molecular cloning and functional characterization of elongase (elovl5) and fatty acyl desaturase (fads2) in sciaenid, Nibea diacanthus (Lacepède, 1802).
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.01.033
Abstract: In the present paper, we investigated the molecular cloning and functional characterization of elongase of very long chain fatty acid (elovl) and fatty acyl desaturase (fads) genes in a marine teleost, Nibea diacanthus. The elongase… read more here.
Keywords: molecular cloning; desaturase; elongase; functional characterization ... See more keywords
Protein engineering: Regulatory perspectives of stearoyl CoA desaturase.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.03.171
Abstract: Stearoyl Co A desaturase (SCD) is a rate-limiting lipogenic enzyme that plays an integral role in catalyzing the synthesis of monounsaturated fatty acids, chiefly oleate and palmitoleate. Both contribute a major part of the biological… read more here.
Keywords: desaturase; stearoyl coa; protein engineering; scd ... See more keywords
Improved γ-Linolenic Acid Production from Cellulose in Mucor circinelloides via Coexpression of Cellobiohydrolase and Delta-6 Desaturase.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c00359
Abstract: The present study was aimed at facilitating the production of γ-linolenic acid (GLA) from the cellulosic substrate with the engineered oleaginous fungus Mucor circinelloides WJ11. Here, the homologous recombination technology was used to overexpress the… read more here.
Keywords: via coexpression; desaturase; production; linolenic acid ... See more keywords
CRISPR/Cas9-mediated Stearoyl-CoA Desaturase 1 (SCD1) Deficiency Affects Fatty Acid Metabolism in Goat Mammary Epithelial Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b03545
Abstract: Stearoyl-CoA desaturase 1 (SCD1) is a fatty acid desaturase catalyzing cis-double-bond formation in the Δ9 position to produce monounsaturated fatty acids essential for the synthesis of milk fat. Previous studies using RNAi methods have provided… read more here.
Keywords: desaturase; crispr cas9; goat mammary; fatty acid ... See more keywords
Discovery of Potent Benzocycloalkane Derived Diapophytoene Desaturase Inhibitors with an Enhanced Safety Profile for the Treatment of MRSA, VISA, and LRSA Infections.
Sign Up to like & getrecommendations! Published in 2018 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.7b00259
Abstract: Blocking the biosynthesis process of staphyloxanthin has emerged as a promising antivirulence strategy. Our previous research revealed that diapophytoene desaturase was an attractive and druggable target against infections caused by pigmented Staphylococcus aureus. Benzocycloalkane-derived compounds… read more here.
Keywords: staphylococcus aureus; desaturase inhibitors; desaturase; benzocycloalkane derived ... See more keywords
FADS1 and FADS2 as biomarkers of Zn status - a systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in food science and nutrition"
DOI: 10.1080/10408398.2022.2103790
Abstract: Despite enormous research efforts, a sufficiently sensitive and reliable biomarker for the assessment of zinc (Zn) status has not been identified to date. Zn affects fatty acid metabolism and alters the activity of certain desaturases;… read more here.
Keywords: desaturase; cis; systematic review; status ... See more keywords
Enzymatic modification by point mutation and functional analysis of an omega-6 fatty acid desaturase from Arctic Chlamydomonas sp.
Sign Up to like & getrecommendations! Published in 2017 at "Preparative Biochemistry and Biotechnology"
DOI: 10.1080/10826068.2016.1188311
Abstract: ABSTRACT Arctic Chlamydomonas sp. is a dominant microalgal strain in cold or frozen freshwater in the Arctic region. The full-length open reading frame of the omega-6 fatty acid desaturase gene (AChFAD6) was obtained from the… read more here.
Keywords: desaturase; arctic chlamydomonas; acid desaturase; fatty acid ... See more keywords
Species-Specific Differences in C-5 Sterol Desaturase Function Influence the Outcome of Azole Antifungal Exposure
Sign Up to like & getrecommendations! Published in 2021 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01044-21
Abstract: The azole antifungals inhibit sterol 14α-demethylase (S14DM), leading to depletion of cellular ergosterol and the synthesis of an aberrant sterol diol that disrupts membrane function. In Candida albicans, sterol diol production is catalyzed by the… read more here.
Keywords: sterol desaturase; desaturase; species specific; sterol diol ... See more keywords
Fatty acid profile and estimated desaturase activities in whole blood are associated with metabolic health
Sign Up to like & getrecommendations! Published in 2020 at "Lipids in Health and Disease"
DOI: 10.1186/s12944-020-01282-y
Abstract: Background The aim was to investigate if fatty acid profile and estimated desaturase activities; stearoyl CoA-desaturase (SCD), delta-5-desaturase and delta-6-desaturase (D5D; D6D), differ between individuals with metabolically healthy (MH) and unhealthy (MU) phenotypes. We also… read more here.
Keywords: desaturase; estimated desaturase; fatty acid; desaturase activities ... See more keywords