Blockade of α2-adrenergic or metabotropic glutamate receptors induces glutamate release in the locus coeruleus to activate descending inhibition in rats with chronic neuropathic hypersensitivity
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DOI: 10.1016/j.neulet.2018.04.011
Abstract: Locus coeruleus (LC)-spinal noradrenergic projections are important to endogenous analgesic mechanisms and can be activated by local glutamate signaling in the LC. The current study examined the local glutamatergic, GABAergic, and noradrenergic influences on glutamate… read more here.
Keywords: descending inhibition; glutamate; locus coeruleus; glutamate release ... See more keywords