Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis.
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DOI: 10.1021/acschembio.3c00167
Abstract: Desferrioxamine siderophores are assembled by the nonribosomal-peptide-synthetase-independent siderophore (NIS) synthetase enzyme DesD via ATP-dependent iterative condensation of three N1-hydroxy-N1-succinyl-cadaverine (HSC) units. Current knowledge of NIS enzymology and the desferrioxamine biosynthetic pathway does not account for… read more here.
Keywords: condensation; desd catalyzes; desferrioxamine biosynthesis; desferrioxamine ... See more keywords