Outcome of desensitization in human leukocyte antigen and ABO incompatible living donor kidney transplantation: Single center experience of first 200 incompatible transplants
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Apheresis"
DOI: 10.1002/jca.21860
Abstract: Although desensitization is well established, concerns about graft outcome, patient survival and rejection still exist. The present study aims at comparing outcomes of renal transplant recipients across simultaneous ABO and human leukocyte antigen (HLA) incompatibility… read more here.
Keywords: human leukocyte; abo; desensitization; leukocyte antigen ... See more keywords
Allosteric targeting of the FFA2 receptor (GPR43) restores responsiveness of desensitized human neutrophils
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2a0720-432r
Abstract: The G protein‐coupled free fatty acid receptor 2 (FFA2R) is highly expressed on neutrophils and was previously described to regulate neutrophil activation. Allosteric targeting of G protein‐coupled receptors (GPCRs) is increasingly explored to create distinct… read more here.
Keywords: activation; receptor; allosteric targeting; human neutrophils ... See more keywords
Temozolomide desensitization followed by metronomic dosing in patients with hypersensitivity
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Chemotherapy and Pharmacology"
DOI: 10.1007/s00280-020-04123-y
Abstract: Temozolomide is the most effective chemotherapy for malignant glioma. Hypersensitivity requiring interruption of therapy may significantly impact patient survival. We have successfully employed temozolomide desensitization followed by metronomic dosing of temozolomide. Our purpose was to… read more here.
Keywords: desensitization followed; temozolomide desensitization; metronomic dosing; hypersensitivity ... See more keywords
The role of β-arrestins in G protein-coupled receptor heterologous desensitization: A brief story.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2018.08.004
Abstract: G protein-coupled receptors (GPCRs) are transmembrane proteins that have an important impact in a myriad of cellular functions. Posttranslational modifications on GPCRs are a key processes that allow these proteins to recruit other intracellular molecules.… read more here.
Keywords: role arrestins; protein coupled; receptor; desensitization ... See more keywords
Fabrication and characterization of CL-20/PEI/GO composites with enhanced thermal stability and desensitization via electrostatic self-assembly
Sign Up to like & getrecommendations! Published in 2021 at "Applied Surface Science"
DOI: 10.1016/j.apsusc.2021.149933
Abstract: Abstract To improve the encapsulation of GO to CL-20, PEI was utilized as a linker bridge to self-assemble into composite CL-20/PEI/GO in this study. The self-assembly was in-depth characterized, including Zeta potential, SEM, DLS, XPS,… read more here.
Keywords: fabrication characterization; pei; desensitization; self assembly ... See more keywords
Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.017
Abstract: P2X receptors are trimeric, non-selective cation channels activated by extracellular ATP. The P2X7 receptor subtype is a pharmacological target because of involvement in apoptotic, inflammatory, and tumor progression pathways. It is the most structurally and… read more here.
Keywords: full length; p2x7; structures reveal; receptor ... See more keywords
Stable desensitization of α7 nicotinic acetylcholine receptors by NS6740 requires interaction with S36 in the orthosteric agonist binding site.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174179
Abstract: NS6740 is an α7 nicotinic acetylcholine receptor-selective partial agonist with low efficacy for channel activation, capable of promoting the stable conversion of the receptors to nonconducting (desensitized) states that can be reactivated with the application… read more here.
Keywords: nicotinic acetylcholine; stable desensitization; binding sites; activation ... See more keywords
A Virtualcrossmatch-Based Strategy for Perioperative Desensitization in Lung Transplant Recipients with Pre-Formed Donor-Specific Antibodies: 3-year Outcome
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.492
Abstract: Purpose Pre-formed donor-specific antibodies (pf-DSA) are associated with worse outcome after lung transplantation (LTx) and might limit access to LTx. A virtual crossmatch (CXM)-based strategy for perioperative desensitization protocol has been used for immunized LTx… read more here.
Keywords: ltx; pre formed; lung; formed donor ... See more keywords
Outcome of Urgent Desensitization in Sensitized Heart Transplant Recipients
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.667
Abstract: Purpose Desensitization therapy through reducing preformed antibody to increase the chances of a negative cross-match or permit safe transplantation across positive crossmatch. There was no consensus regarding desensitization protocol in cardiac patients, and the outcome… read more here.
Keywords: desensitization; sensitized heart; rejection; heart transplant ... See more keywords
Doxycycline desensitization in chronic Q fever—A critical tool for the clinician
Sign Up to like & getrecommendations! Published in 2018 at "IDCases"
DOI: 10.1016/j.idcr.2018.01.006
Abstract: We present the case of a 45 year old woman with acute Q fever pneumonia who progressed to the chronic phase of the disease despite azithromycin therapy. A trial of doxycycline was halted because of severe… read more here.
Keywords: desensitization chronic; fever critical; doxycycline; desensitization ... See more keywords
Chronic fluoxetine reverses the effects of chronic corticosterone treatment on α2-adrenoceptors in the rat frontal cortex but not locus coeruleus
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107731
Abstract: Disruption of the hypothalamic-pituitary-adrenal axis is an established finding in patients with anxiety and/or depression. Chronic corticosterone administration in animals has been proposed as a model for the study of these stress-related disorders and the… read more here.
Keywords: corticosterone; treatment; effect; fluoxetine ... See more keywords