Metabolism of highly potent synthetic opioid nitazene analogs: N-ethyl-N-(1-glucuronyloxyethyl) metabolite formation and degradation to N-desethyl metabolites during enzymatic hydrolysis.
Sign Up to like & getrecommendations! Published in 2024 at "Drug testing and analysis"
DOI: 10.1002/dta.3705
Abstract: The metabolism of the highly potent synthetic opioids metonitazene, etonitazene, and protonitazene was investigated in fresh human hepatocytes. In the hydrolyzed culture medium, N-desethyl-, N,N-di-desethyl-, O-desalkyl-, N-desethyl-O-desalkyl-, N,N-di-desethyl-O-desalkyl-, and N-oxidated metabolites were detected as phase… read more here.
Keywords: metabolism highly; desethyl; phase metabolites; ethyl glucuronyloxyethyl ... See more keywords