Analytical aspects of sunitinib and its geometric isomerism towards therapeutic drug monitoring in clinical routine
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2018.08.013
Abstract: HIGHLIGHTSSunitinib is a tyrosine kinase inhibitor and a candidate for TDM approach.Sunitinib and N‐desethyl sunitinib undergo light‐induced Z/E isomerization.Sample handling/analysis require light protection to preserve the active Z‐form.A fast and quantitative reconversion of the E‐… read more here.
Keywords: isomer; clinical routine; sunitinib; therapeutic drug ... See more keywords