Synthesis of modular desferrioxamine analogues and evaluation of zwitterionic derivatives for zirconium complexation.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202300112
Abstract: The natural siderophore desferrioxamine B (DFOB) has been used for targeted PET imaging with 89Zr before. However, Zr-DFOB has a limited stability and a number of derivatives have been developed with improved chelation properties for… read more here.
Keywords: complexation; synthesis; stability; desferrioxamine ... See more keywords
Causes of hospital admission in children and adults with transfusion-dependent thalassemia in Sardinia, 2000–2015
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Hematology"
DOI: 10.1007/s00277-017-2963-4
Abstract: Dear Editor, Since its opening in the 1980s, II Clinica Pediatrica at Ospedale Microcitemico BA.Cao^ in Cagliari, Italy has been the reference for all types of medical conditions occurring in thalassemia major (TM) patients of… read more here.
Keywords: hospital admission; desferrioxamine; admission; age ... See more keywords
Imaging Somatostatin Positive Tumors with Tyr3-Octreotate/Octreotide Conjugated to Desferrioxamine B Squaramide Radiolabeled with either Zirconium-89 or Gallium-68.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00109
Abstract: Radiolabeled derivatives of Tyr3-octreotide and Tyr3-octreotate, synthetic analogues of the peptide hormone somatostatin, can be used for positron emission tomography (PET) imaging of somatostatin receptor expression in neuroendocrine tumors. In this work, a squaramide ester… read more here.
Keywords: imaging somatostatin; desferrioxamine; h3dfosq; gallium ... See more keywords
Acetyl-CoA-Mediated Post-Biosynthetic Modification of Desferrioxamine B Generates N- and N-O-Acetylated Isomers Controlled by a pH Switch.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00879
Abstract: Biosynthesis of the hydroxamic acid siderophore desferrioxamine D1 (DFOD1, 6), which is the N-acetylated analogue of desferrioxamine B (DFOB, 5), has been delineated. Enzyme-independent Ac-CoA-mediated N-acetylation of 5 produced 6, in addition to three constitutional… read more here.
Keywords: modification; post biosynthetic; acetylated isomers; coa mediated ... See more keywords
Siderophore Synthetase DesD Catalyzes N-to-C Condensation in Desferrioxamine Biosynthesis.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical biology"
DOI: 10.1021/acschembio.3c00167
Abstract: Desferrioxamine siderophores are assembled by the nonribosomal-peptide-synthetase-independent siderophore (NIS) synthetase enzyme DesD via ATP-dependent iterative condensation of three N1-hydroxy-N1-succinyl-cadaverine (HSC) units. Current knowledge of NIS enzymology and the desferrioxamine biosynthetic pathway does not account for… read more here.
Keywords: condensation; desd catalyzes; desferrioxamine biosynthesis; desferrioxamine ... See more keywords
Actinobacteria phylogenomics, selective isolation from an iron oligotrophic environment and siderophore functional characterization, unveil new desferrioxamine traits
Sign Up to like & getrecommendations! Published in 2017 at "FEMS Microbiology Ecology"
DOI: 10.1093/femsec/fix086
Abstract: ABSTRACT Desferrioxamines are hydroxamate siderophores widely conserved in both aquatic and soil‐dwelling Actinobacteria. While the genetic and enzymatic bases of siderophore biosynthesis and their transport in model families of this phylum are well understood, evolutionary… read more here.
Keywords: selective isolation; desferrioxamine; phylogenomics selective; actinobacteria phylogenomics ... See more keywords