Desialylation of Platelets by Pneumococcal Neuraminidase A Induces ADP-Dependent Platelet Hyperreactivity
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DOI: 10.1128/iai.00213-18
Abstract: Platelets are increasingly recognized to play a role in the complications of Streptococcus pneumoniae infections. S. pneumoniae expresses neuraminidases, which may alter glycans on the platelet surface. ABSTRACT Platelets are increasingly recognized to play a… read more here.
Keywords: platelet hyperreactivity; pneumococcal neuraminidase; platelet; desialylation ... See more keywords
Effects of genetic variants and sialylation on in vitro digestibility of purified κ-casein.
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DOI: 10.3168/jds.2021-21289
Abstract: Milk with different κ-casein (CN) phenotypes has previously been found to influence its gastric digestion rate. Therefore, the aim of the present study is to disentangle contributions of genetic variation and its related sialylation on… read more here.
Keywords: desialylation; digestibility; sialylation vitro; vitro digestion ... See more keywords
Myristica fragrans Extract Inhibits Platelet Desialylation and Activation to Ameliorate Sepsis-Associated Thrombocytopenia in a Murine CLP-Induced Sepsis Model
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DOI: 10.3390/ijms24108863
Abstract: Sepsis, characterized by an uncontrolled host inflammatory response to infections, remains a leading cause of death in critically ill patients worldwide. Sepsis-associated thrombocytopenia (SAT), a common disease in patients with sepsis, is an indicator of… read more here.
Keywords: sepsis; platelet desialylation; desialylation; desialylation activation ... See more keywords
Platelet Desialylation Is a Novel Mechanism and Therapeutic Target in Daboia siamensis and Agkistrodon halys Envenomation-Induced Thrombocytopenia
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DOI: 10.3390/molecules27227779
Abstract: Venom-induced thrombocytopenia (VIT) is one of the most important hemotoxic effects of a snakebite, which is often associated with venom-induced consumptive coagulopathy (VICC). Refractory thrombocytopenia without significant coagulation abnormalities has also been reported after envenomation… read more here.
Keywords: envenomation; venom induced; desialylation; induced thrombocytopenia ... See more keywords