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Empirical Evaluations of Clinical Trial Designs.

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1 Published in 2022 at "JAMA network open"

DOI: 10.1001/jamanetworkopen.2022.11620

Abstract: present an insightful comparison of 2 clinical trial designs: (1) the actual study design that was implemented in the Stroke Hyperglycemia Insulin Network Effort (SHINE) trial 2 and (2) an alternative nonimplemented design. This comparison… read more here.

Keywords: trial designs; empirical evaluations; trial; design ... See more keywords

Clinical Trial Design Challenges and Opportunities for Emerging Treatments for Opioid Use Disorder: A Review.

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1 Published in 2022 at "JAMA psychiatry"

DOI: 10.1001/jamapsychiatry.2022.4020

Abstract: Importance Novel treatments for opioid use disorder (OUD) are needed to address both the ongoing opioid epidemic and long-standing barriers to existing OUD treatments that target the endogenous μ-opioid receptor (MOR) system. The goal of… read more here.

Keywords: clinical trial; trial; design; opioid use ... See more keywords

Engineering protein fragments via evolutionary and protein–protein interaction algorithms: de novo design of peptide inhibitors for FOF1‐ATP synthase

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0 Published in 2020 at "FEBS Letters"

DOI: 10.1002/1873-3468.13988

Abstract: Enzyme subunit interfaces have remarkable potential in drug design as both target and scaffold for their own inhibitors. We show an evolution‐driven strategy for the de novo design of peptide inhibitors targeting interfaces of the… read more here.

Keywords: protein; atp synthase; peptide; novo design ... See more keywords

Dual beam‐current transformer design for monitoring and reporting of electron ultra‐high dose rate (FLASH) beam parameters

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3 Published in 2023 at "Journal of Applied Clinical Medical Physics"

DOI: 10.1002/acm2.13891

Abstract: Abstract Purpose To investigate the usefulness and effectiveness of a dual beam‐current transformer (BCTs) design to monitor and record the beam dosimetry output and energy of pulsed electron FLASH (eFLASH) beams in real‐time, and to… read more here.

Keywords: beam; energy; bct; design ... See more keywords

Elastic Biomaterial Scaffold with Spatially Varying Adhesive Design

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0 Published in 2020 at "Advanced Biosystems"

DOI: 10.1002/adbi.202000046

Abstract: In order to secure biomaterials to tissue surfaces, sutures or glues are commonly used. Of interest is the development of a biomaterial patch for applications in tissue engineering and regeneration that incorporates an adhesive component… read more here.

Keywords: scaffold spatially; patch; tissue; biomaterial scaffold ... See more keywords

Recent Advances in the Design and Fabrication of Strong and Ductile (Tensile) Titanium Metal Matrix Composites

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1 Published in 2019 at "Advanced Engineering Materials"

DOI: 10.1002/adem.201801331

Abstract: Titanium metal matrix composites (TiMMCs) offer much improved strength, elastic modulus, and wear resistance at both room and elevated temperatures but often at the expense of tensile ductility, which excludes them from most key engineering… read more here.

Keywords: design fabrication; titanium metal; matrix composites; recent advances ... See more keywords

A Property‐Driven Stepwise Design Strategy for Multiple Low‐Melting Alloys via Machine Learning

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1 Published in 2021 at "Advanced Engineering Materials"

DOI: 10.1002/adem.202100612

Abstract: Low‐melting alloys (LMAs) have an extensive application prospect due to their extremely low melting points for further research of other properties. However, it is difficult to design new multiple alloys with required melting point based… read more here.

Keywords: stepwise; strategy; melting alloys; melting point ... See more keywords

Design Study for Multifunctional 3D Re‐entrant Auxetics

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1 Published in 2021 at "Advanced Engineering Materials"

DOI: 10.1002/adem.202100816

Abstract: The increasing demands of safety, cost reduction, or weight reduction on components call for new, multifunctional materials. Mechanical metamaterials, such as auxetic materials, provide enhanced properties due to a specially tailored microstructure. The negative Poisson's… read more here.

Keywords: design; study multifunctional; design study; multifunctional entrant ... See more keywords

Structure–Thermodynamic‐Property Relationships in Cyanovinyl‐Based Microporous Polymer Networks for the Future Design of Advanced Carbon Capture Materials

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0 Published in 2017 at "Advanced Functional Materials"

DOI: 10.1002/adfm.201700233

Abstract: Nitrogen‐rich solid absorbents, which have been immensely tested for carbon dioxide capture, seem until this date to be without decisive molecular engineering or design rules. Here, a family of cyanovinylene‐based microporous polymers synthesized under metal‐catalyzed… read more here.

Keywords: advanced carbon; based microporous; carbon; carbon capture ... See more keywords

Fundamental Theory of Biodegradable Metals—Definition, Criteria, and Design

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0 Published in 2019 at "Advanced Functional Materials"

DOI: 10.1002/adfm.201805402

Abstract: Until now there has been no fundamental theory applicable for biodegradable metals (BMs). First, this paper optimizes the definition of BMs given in 2014. Second, the dual criteria of biodegradability and biocompatibility are proposed for… read more here.

Keywords: definition; biodegradable metals; biocompatibility; fundamental theory ... See more keywords

Integrated Thin Film Battery Design for Flexible Lithium Ion Storage: Optimizing the Compatibility of the Current Collector‐Free Electrodes

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0 Published in 2019 at "Advanced Functional Materials"

DOI: 10.1002/adfm.201903542

Abstract: The design of flexible full‐cell configuration relies on the light‐weight arrangement, structural robustness, compositional compatibility, and shape conformability of the coherent components. In this article, a general and scalable spin‐coating approach is developed to integrate… read more here.

Keywords: design flexible; current collector; collector free; thin film ... See more keywords