Design and Biological Evaluation of Manganese‐ and Ruthenium‐Based Hybrid CO‐RMs (HYCOs)
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DOI: 10.1002/cmdc.201900426
Abstract: Interest in the therapeutic effects of carbon monoxide (CO), a product of heme degradation catalyzed by the enzyme heme oxygenase‐1 (HO‐1), has led to the development of CO‐releasing molecules (CO‐RMs) for the controlled delivery of… read more here.
Keywords: biological evaluation; ruthenium based; manganese ruthenium; design biological ... See more keywords
Design, Biological Evaluation, and Computer-Aided Analysis of Dihydrothiazepines as Selective Antichlamydial Agents.
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DOI: 10.1021/acs.jmedchem.2c01894
Abstract: Chlamydia trachomatis (CT) causes the most prevalent sexually transmitted bacterial disease in the United States. The lack of drug selectivity is one of the main challenges of the current antichlamydial pharmacotherapy. The metabolic needs of… read more here.
Keywords: design biological; aided analysis; biological evaluation; selective antichlamydial ... See more keywords
Design, biological evaluation, and molecular modelling insights of cupressic acid derivatives as promising anti-inflammatory agents
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DOI: 10.1080/14756366.2023.2187327
Abstract: Abstract The major labdanes in the oleogum resin of Araucaria heterophylla (Salisb.) Franco, 13-epi-cupressic acid (1) and acetyl-13-epi-cupressic acid (2) were used to prepare seven new (3–9), along with one known (10) derivatives. RAW264.7 cells… read more here.
Keywords: design biological; inflammatory agents; anti inflammatory; cupressic acid ... See more keywords
Design and biological characterization of novel cell-penetrating peptides preferentially targeting cell nuclei and subnuclear regions
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DOI: 10.3762/bjoc.14.116
Abstract: Within this study, we report about the design and biological characterization of novel cell-penetrating peptides (CPPs) with selective suborganelle-targeting properties. The nuclear localization sequence N50, as well as the nucleoli-targeting sequence NrTP, respectively, were fused… read more here.
Keywords: characterization novel; cell penetrating; design biological; biological characterization ... See more keywords