Therapeutic DNAzymes: From Structure Design to Clinical Applications.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202300374
Abstract: Therapeutic DNAzymes have unceasingly intrigued the scientific community owing to their prosperous gene regulation capability. The efficacy of DNAzymes against many types of diseases has been extensively studied for over two decades. However, the high… read more here.
Keywords: clinical applications; design; design clinical; therapeutic dnazymes ... See more keywords
The Design of Clinical Trials in Portal Hypertension.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in liver disease"
DOI: 10.1055/s-0036-1597891
Abstract: Portal hypertension (PH) is the main consequence of cirrhosis and is responsible for the majority of its complications. Gastroesophageal varices and variceal hemorrhage are direct consequences of PH; therefore, most clinical trials in PH have… read more here.
Keywords: portal hypertension; variceal hemorrhage; clinical trials; design clinical ... See more keywords
FRI0607 How to design clinical trials to be more patient oriented: an example from preventative treatments for rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.5712
Abstract: Background It is widely acknowledged that many clinical trials do not always provide results that are meaningful to patients. We sought to utilise market research techniques, widely used in non-health consumer product development, to understand… read more here.
Keywords: risk; design; clinical trials; preventative treatments ... See more keywords
Report of the 14th International Conference on Malignant Lymphoma (ICML) Closed Workshop on Future Design of Clinical Trials in Lymphomas
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-17-3021
Abstract: The 14th ICML held in Lugano in June 2017 was preceded by a closed workshop (organized in collaboration with the American Association for Cancer Research and the European School of Oncology) where experts in preclinical… read more here.
Keywords: lymphoma; closed workshop; report; clinical trials ... See more keywords
A Bayesian adaptive design for clinical trials of rare efficacy outcomes with multiple definitions
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Trials"
DOI: 10.1177/17407745221118366
Abstract: Introduction: Bayesian adaptive designs for clinical trials have gained popularity in the recent years due to the flexibility and efficiency that they offer. We consider the scenario where the outcome of interest comprises events with… read more here.
Keywords: clinical trials; adaptive design; bayesian adaptive; trials rare ... See more keywords
Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application.
Sign Up to like & getrecommendations! Published in 2018 at "Current medicinal chemistry"
DOI: 10.2174/0929867325666180214111849
Abstract: Endoplasmic Reticulum aminopeptidase 1 and 2 are two homologous enzymes that help generate peptide ligands for presentation by Major Histocompatibility Class I molecules. Their enzymatic activity influences the antigenic peptide repertoire and indirectly controls adaptive… read more here.
Keywords: aminopeptidase design; chemistry; inhibitors aminopeptidase; design clinical ... See more keywords
Automatic drawing of customized removable partial denture diagrams based on textual design for the clinical decision support system.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of oral science"
DOI: 10.2334/josnusd.19-0138
Abstract: Qualified diagrams of removable partial denture (RPD) designs created by dentists provide technicians with clear and dynamic information. Generating RPD design in the clinical decision support system (CDSS) can be achieved by producing the RPD… read more here.
Keywords: rpd; removable partial; design clinical; clinical decision ... See more keywords
Antimicrobial Peptides: From Design to Clinical Application
Sign Up to like & getrecommendations! Published in 2022 at "Antibiotics"
DOI: 10.3390/antibiotics11030349
Abstract: Infection of multidrug-resistant (MDR) bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), carbapenem-resistant Enterobacteriaceae (CRE), and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli, brings public health issues and causes economic burden. Pathogenic bacteria develop several methods to resist… read more here.
Keywords: application; antibiotic resistance; clinical application; peptides design ... See more keywords