The Limits and Hazards of Clinical Equipoise on Cardiology Study Design and Conduct
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DOI: 10.1001/jamacardio.2018.1691
Abstract: Cardiology has been a leading field in generating evidence through large randomized clinical trials (RCTs). The principle of clinical equipoise is widely endorsed as a foundational ethical requirement governing design and conduct of RCTs.1 Clinical… read more here.
Keywords: cardiology; clinical equipoise; equipoise cardiology; design conduct ... See more keywords
Design, Conduct, and Analysis of Externally Controlled Trials
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DOI: 10.1001/jamanetworkopen.2025.30277
Abstract: Key Points Question How are externally controlled trials (ECTs) currently designed, conducted, and analyzed in practice, and do they use methods, such as statistical methods, to control bias? Findings In this cross-sectional analysis of 180… read more here.
Keywords: conduct analysis; controlled trials; externally controlled; analysis externally ... See more keywords
Value of preclinical systematic reviews and meta-analyses in pediatric research
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DOI: 10.1038/s41390-024-03197-1
Abstract: Similar to systematic reviews (SRs) in clinical fields, preclinical SRs address a specific research area, furnishing information on current knowledge, possible gaps, and potential methodological flaws of study design, conduct, and report. One of the… read more here.
Keywords: age; pediatric research; systematic reviews; design conduct ... See more keywords
Design and conduct of confirmatory chronic pain clinical trials
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DOI: 10.1097/pr9.0000000000000854
Abstract: This article provides a set of practical, evidence-based suggestions for designing and executing chronic pain clinical trials in a manner that minimizes measurement error. read more here.
Keywords: pain; pain clinical; conduct confirmatory; chronic pain ... See more keywords
The ethical challenges raised in the design and conduct of pragmatic trials: an interview study with key stakeholders
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DOI: 10.1186/s13063-019-3899-x
Abstract: There is a concern that the apparent effectiveness of interventions tested in clinical trials may not be an accurate reflection of their actual effectiveness in usual practice. Pragmatic randomized controlled trials (RCTs) are designed with… read more here.
Keywords: pragmatic rcts; design conduct; ethical challenges; key stakeholders ... See more keywords