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Published in 2018 at "JAMA Cardiology"
DOI: 10.1001/jamacardio.2018.1691
Abstract: Cardiology has been a leading field in generating evidence through large randomized clinical trials (RCTs). The principle of clinical equipoise is widely endorsed as a foundational ethical requirement governing design and conduct of RCTs.1 Clinical…
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Keywords:
cardiology;
clinical equipoise;
equipoise cardiology;
design conduct ... See more keywords
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Published in 2021 at "Pain Reports"
DOI: 10.1097/pr9.0000000000000854
Abstract: This article provides a set of practical, evidence-based suggestions for designing and executing chronic pain clinical trials in a manner that minimizes measurement error.
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Keywords:
pain;
pain clinical;
conduct confirmatory;
chronic pain ... See more keywords
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Published in 2019 at "Trials"
DOI: 10.1186/s13063-019-3899-x
Abstract: There is a concern that the apparent effectiveness of interventions tested in clinical trials may not be an accurate reflection of their actual effectiveness in usual practice. Pragmatic randomized controlled trials (RCTs) are designed with…
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Keywords:
pragmatic rcts;
design conduct;
ethical challenges;
key stakeholders ... See more keywords