Design of Cyclic Peptides as Protein Recognition Motifs.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9504-2_6
Abstract: Protein-protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic intervention. Linear peptide drugs, however, can be applied therapeutically as protein recognition motifs only to a limited extent… read more here.
Keywords: protein recognition; design cyclic; recognition motifs; peptides protein ... See more keywords
Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23609-8
Abstract: Despite recent success in computational design of structured cyclic peptides, de novo design of cyclic peptides that bind to any protein functional site remains difficult. To address this challenge, we develop a computational “anchor extension”… read more here.
Keywords: design cyclic; anchor extension; approach; cyclic peptides ... See more keywords