Design and Evaluation of Biodegradable Self‐Immolative Lipids for RNA Delivery
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202501305
Abstract: Lipid nanoparticle (LNP) is a proven platform for the safe and efficacious delivery of nucleic acid‐based therapeutics. Regulatory approvals of Patisiran, and mRNA vaccines against Covid‐19 are testaments to this fact. A key requisite for… read more here.
Keywords: self immolative; biodegradable self; delivery; immolative lipids ... See more keywords
Microgripper design and evaluation for automated µ-wire assembly: a survey
Sign Up to like & getrecommendations! Published in 2020 at "Microsystem Technologies"
DOI: 10.1007/s00542-019-04741-4
Abstract: Microgrippers are commonly used for micromanipulation of micro-objects from 1 to 100 µm and attain features of reliable accuracy, low cost, wide jaw aperture and variable applied force. This paper aim is to review the design… read more here.
Keywords: automated wire; wire; design evaluation; evaluation automated ... See more keywords
Design and evaluation of automated writing evaluation models: Relationships with writing in naturalistic settings
Sign Up to like & getrecommendations! Published in 2017 at "Assessing Writing"
DOI: 10.1016/j.asw.2017.10.001
Abstract: Abstract Automated Writing Evaluation (AWE)systems are built by extracting features from a 30 min essay and using a statistical model that weights those features to optimally predict human scores on the 30 min essays. But the goal… read more here.
Keywords: writing evaluation; automated writing; model; evaluation ... See more keywords
Design evaluation of hardwired F-LIC module for ITER AC/DC converters by FMEDA method
Sign Up to like & getrecommendations! Published in 2020 at "Fusion Engineering and Design"
DOI: 10.1016/j.fusengdes.2019.111417
Abstract: Abstract The Fast Local Interlock Controllers (F-LIC) are important components for the fast protection of ITER AC/DC converters and super conducting coils in the event of quench or converter faults. When the quench signal or… read more here.
Keywords: iter converters; hardwired lic; evaluation; design evaluation ... See more keywords
Rational approach for design and evaluation of anti-aggregation agents for protein stabilization: A case study of trehalose phenylalaninate.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.03.075
Abstract: The present work introduces new anti-aggregation agent (AAA) derived through our new approach for design and evaluation of anti-aggregation agent as a multi-purpose excipient to combat protein aggregation. Therapeutic proteins undergo aggregation due to even… read more here.
Keywords: aggregation; tpa; approach design; anti aggregation ... See more keywords
Design and Evaluation of [18F]CHDI-650 as a Positron Emission Tomography Ligand to Image Mutant Huntingtin Aggregates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01585
Abstract: Therapeutic interventions are being developed for Huntington's disease (HD), a hallmark of which is mutant huntingtin protein (mHTT) aggregates. Following the advancement to human testing of two [11C]-PET ligands for aggregated mHTT, attributes for further… read more here.
Keywords: chdi 650; design evaluation; mutant huntingtin; ligand ... See more keywords
Design and evaluation of octopromycin-derived peptides as multifunctional antimicrobial agents against multidrug-resistant pathogens
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-25213-y
Abstract: Octopromycin (OPM), an antimicrobial peptide from Octopus minor, shows potent activity against multidrug-resistant (MDR) Acinetobacter baumannii. Guided by the structure–activity relationship of the N-terminal domain OPM23, we designed short α-helical peptides with enhanced antimicrobial, anti-inflammatory,… read more here.
Keywords: derived peptides; multidrug resistant; evaluation octopromycin; anti inflammatory ... See more keywords
Design and evaluation of novel thrombin-based GLP-1 analogs with peptidic albumin binding domain for the controlled release of GLP-1
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra00104j
Abstract: Currently, the curative effects of polypeptide drugs are often restricted due to the short in vivo duration of action. In this study, we fused a series of heptapeptide tags with different length fatty chains to… read more here.
Keywords: evaluation novel; albumin binding; glp; thrombin based ... See more keywords
Unifying principles for the design and evaluation of natural product-inspired compound collections
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Science"
DOI: 10.1039/d4sc08017c
Abstract: Natural products play a major role in the discovery of novel bioactive compounds. In this regard, the synthesis of natural product-inspired and -derived analogues is an active field that is further developing. Several strategies and… read more here.
Keywords: unifying principles; principles design; natural product; design evaluation ... See more keywords
Design and Evaluation of Dansyl-Derived Chemosensors for Disulfide-Cleavage-Triggered Detection: Photophysical, Metal Sensing, and Thermometric Applications
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Materials Chemistry C"
DOI: 10.1039/d4tc04750h
Abstract: In this work, two new dansyl-derived chemosensors have been designed with the aim of developing a disulfide-cleavage-triggered probe. These stable new ligands, containing a thioether (L1) and a disulfide bridge... read more here.
Keywords: cleavage triggered; dansyl derived; derived chemosensors; disulfide cleavage ... See more keywords
Design and Evaluation of Novel Energetic Materials Based on Tricyclo[3.1.1.12,4]
Sign Up to like & getrecommendations! Published in 2025 at "New Journal of Chemistry"
DOI: 10.1039/d5nj00775e
Abstract: A novel series of high-energy density compounds based on the Tricyclic[3.1.1.12,4]octane skeleton has been designed. Four of these compounds exhibit theoretical densities exceeding 1.90 g·cm⁻³, detonation velocities surpassing 9.0 km·s⁻¹,... read more here.
Keywords: energetic materials; evaluation novel; based tricyclo; novel energetic ... See more keywords