Design of experiment assisted concurrent enantioseparation of bupropion and hydroxybupropion by high-performance thin-layer chromatography.
Sign Up to like & getrecommendations! Published in 2017 at "Chirality"
DOI: 10.1002/chir.22673
Abstract: A simple and efficient high-performance thin-layer chromatographic method was developed for chiral separation of rac-bupropion (BUP) and its active metabolite rac-hydroxybupropion (HBUP). Design of experiment (DoE)-based optimization was adopted instead of a conventional trial-and-error approach.… read more here.
Keywords: design experiment; performance thin; thin layer; high performance ... See more keywords
Heat Treatment Map of Al2Ca-added AlSi11MnMg Pressure-Cast Alloy Plotted by Full Factorial Design of Experiment and Analysis of Variance
Sign Up to like & getrecommendations! Published in 2019 at "Metal Science and Heat Treatment"
DOI: 10.1007/s11041-019-00454-7
Abstract: The methods of design of experiment (DOE), analysis of variance (ANOVA) and response surface (RS) are used to study the effect of heat treatment on the microstructure and mechanical properties of a novel AlSi11MgMn pressure-cast… read more here.
Keywords: design experiment; heat treatment; treatment;
Dermal flurbiprofen nanosuspensions: Optimization with design of experiment approach and in vitro evaluation
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.07.009
Abstract: &NA; Flurbiprofen (FB) is the one of the non‐steroidal anti‐inflammatory drugs (NSAIDs) which has low water solubility and dissolution. Nanosuspensions are promising drug delivery systems consisting pure drug particles to overcome poor water solubility issues.… read more here.
Keywords: water solubility; design experiment; solubility; vitro ... See more keywords
Development of solidified self-microemulsifying drug delivery systems containing l-tetrahydropalmatine: Design of experiment approach and bioavailability comparison.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.12.027
Abstract: The study first aimed to apply a design of experiment (DoE) approach to investigate the influences of excipients on the properties of liquid self-microemulsifying drug delivery system (SMEDDS) and SMEDDS loaded in the pellet (pellet-SMEDDS)… read more here.
Keywords: self microemulsifying; design experiment; pellet smedds; bioavailability ... See more keywords
Optimizing the metribuzin degrading potential of a novel bacterial consortium based on Taguchi design of experiment.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2018.11.054
Abstract: Metribuzin (MB) is used for control of weeds in crops like potato, maize and sugarcane. Its extensive and unjudicial use has resulted in various environmental issues; hence it is very critical to remediate this herbicide… read more here.
Keywords: degradation; metribuzin; consortium; taguchi design ... See more keywords
Optimization of Factor Combinations for Stem Cell Differentiations on a Design-of-Experiment Microfluidic Chip.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c03488
Abstract: Directed differentiation of stem cells plays a vital role in cell replacement therapy. Many activators and inhibitors targeting different signaling pathways have been identified to contribute to each step of differentiation. Most studies relied on… read more here.
Keywords: microfluidic chip; design experiment; differentiation; factor combinations ... See more keywords
Design of Experiment Approach to Modeling the Effects of Formulation and Drug Loading on the Structure and Properties of Therapeutic Nanogels
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.1c00699
Abstract: The physical properties of nanoparticles may affect the uptake mechanism, biodistribution, stability, and other physicochemical properties of drug delivery systems. This study aimed to first develop a model exploring the factors controlling the nanogel physical… read more here.
Keywords: structure; drug loading; formulation drug; drug ... See more keywords
Preliminary Study on Sustainable NPK Slow-Release Fertilizers Based on Byproducts and Leftovers: A Design-of-Experiment Approach
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c03082
Abstract: In this study, an organic nitrogen-based coating was developed based on black soldier fly (BSF) prepupae reared on poultry dejections and deposited on ceramic lightweight aggregates (LWAs), containing phosphorous (P) and potassium (K) from agroresidues,… read more here.
Keywords: design experiment; release fertilizers; study; slow release ... See more keywords
Application of statistical design of experiment to identify key factors in cross coupling reactions
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-27005-w
Abstract: The statistical design of experiment (sDoE) enables efficient exploration of complex chemical space by screening multiple factors simultaneously, overcoming the limitations of the one-factor-at-a-time (OFAT) approaches. In this study, Plackett–Burman design (PBD) was applied to… read more here.
Keywords: cross coupling; design experiment; statistical design; coupling reactions ... See more keywords
Design of experiment (DOE) and process optimisation of palladium catalysed biphenyl synthesis
Sign Up to like & getrecommendations! Published in 2024 at "Indian Chemical Engineer"
DOI: 10.1080/00194506.2024.2347268
Abstract: ABSTRACT The effects of time, temperature and catalyst concentration were investigated for an optimised condition of biphenyl synthesis by Suzuki-Miyaura cross-coupling reactions by Neolyst catalysts. The optimisation process was analysed using Box Behnken Face-Centred Experimental… read more here.
Keywords: process; biphenyl synthesis; design experiment; design ... See more keywords
Failure Mode Critical Effect Analysis and Design of Experiment-Based Robust Chromatographic Method for Simultaneous Estimation Lornoxicam and Eperisone Hydrochloride.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chromatographic science"
DOI: 10.1093/chromsci/bmaa064
Abstract: Failure mode critical effect analysis and design of experiment-based high performance thin layer chromatography (HPTLC) method has been developed for simultaneous estimation of lornoxicam (LOC) and eperisone hydrochloride (EPR). Failure modes were identified on the… read more here.
Keywords: design experiment; failure; failure mode; method ... See more keywords