Computational design of fusion proteins against ErbB2-amplified tumors inspired by ricin toxin
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1098365
Abstract: Although the anti-cancer activity of ricin is well-known, its non-specific targeting challenges the development of ricin-derived medicines. In the present study, novel potential ribosome-inactivating fusion proteins (RIPs) were computationally engineered by incorporation of an ErbB2-dependant… read more here.
Keywords: proteins erbb2; fusion proteins; design fusion; ricin ... See more keywords