De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy.
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DOI: 10.1038/nchem.2846
Abstract: Protein catalysis requires the atomic-level orchestration of side chains, substrates and cofactors, and yet the ability to design a small-molecule-binding protein entirely from first principles with a precisely predetermined structure has not been demonstrated. Here… read more here.
Keywords: protein; design hyperstable; ligand; novo design ... See more keywords