Toward the Design of Ligands Selective for the C-Terminal Domain of TEADs.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00075
Abstract: The Hippo signaling pathway plays a fundamental role in the control of organ growth, cell proliferation, and stem cell characters. TEADs are the main transcriptional output regulators of the Hippo signaling pathway and bind to… read more here.
Keywords: terminal domain; selective terminal; ligands selective; design ligands ... See more keywords
AI-assisted design of ligands for lipocalin-2
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1631868
Abstract: Lipocalin-2 (LCN2) is an acute-phase glycoprotein whose upregulation is linked to blood– brain-barrier breakdown and neuroinflammation, making it an attractive diagnostic and therapeutic target. We developed an end-to-end, AI-guided workflow to rapidly design de-novo miniproteins… read more here.
Keywords: assisted design; design ligands; ligands lipocalin; design ... See more keywords