Cell Factory Design and Optimization for the Stereoselective Synthesis of Polyhydroxylated Compounds
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201700464
Abstract: A synthetic cascade for the transformation of primary alcohols into polyhydroxylated compounds in Escherichia coli, through the in situ preparation of cytotoxic aldehyde intermediates and subsequent aldolase‐mediated C−C bond formation, has been investigated. An enzymatic… read more here.
Keywords: factory design; design optimization; polyhydroxylated compounds; optimization stereoselective ... See more keywords
Design and optimization of a fused‐silica microfluidic device for separation of trivalent lanthanides by isotachophoresis
Sign Up to like & getrecommendations! Published in 2019 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201900027
Abstract: Elemental analysis of rare earth elements is essential in a variety of fields including environmental monitoring and nuclear safeguards; however, current techniques are often labor intensive, time consuming, and/or costly to perform. The difficulty arises… read more here.
Keywords: fused silica; silica microfluidic; time; design optimization ... See more keywords
Design optimization and simulated performance evaluation of a self‐collimated cardiac SPECT with simultaneous high sensitivity and resolution
Sign Up to like & getrecommendations! Published in 2025 at "Medical Physics"
DOI: 10.1002/mp.17877
Abstract: Cardiac single photon emission computed tomography (SPECT) is an important noninvasive molecular imaging technology for the diagnosis and risk stratification of heart diseases. However, since its inception, the clinical impact of cardiac SPECT has been… read more here.
Keywords: design optimization; resolution; performance; cardiac spect ... See more keywords
Mesh Stiffener Design and Optimization for Carbon Fiber‐Reinforced B‐pillar Considering Dynamic Impact
Sign Up to like & getrecommendations! Published in 2025 at "Polymer Composites"
DOI: 10.1002/pc.70249
Abstract: In this work, the reinforcement design and optimization method integrating the superelement model and equivalent static load method (ESLM) is proposed for the lower impact region of carbon fiber‐reinforced thermoplastic composite (CFRTP) B‐pillars for automobiles.… read more here.
Keywords: carbon fiber; design optimization; stiffener; model ... See more keywords
Likelihood-based representation of epistemic uncertainty and its application in robustness-based design optimization
Sign Up to like & getrecommendations! Published in 2017 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-017-1684-6
Abstract: In this paper, we propose a new likelihood-based methodology to represent epistemic uncertainty described by sparse point and/or interval data for input variables in uncertainty analysis and design optimization problems. A worst-case maximum likelihood-based approach… read more here.
Keywords: likelihood based; design optimization; epistemic uncertainty; uncertainty ... See more keywords
Kriging-assisted design optimization of the impeller geometry for an automotive torque converter
Sign Up to like & getrecommendations! Published in 2018 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-017-1857-3
Abstract: To reduce the total design and optimization time, numerical analysis with Kriging surrogate model coupled with a multi-objective optimization method based on non-dominated sorting genetic algorithm II (NSGA-II) is used to design optimum impellers for… read more here.
Keywords: torque converter; design optimization; geometry; optimization ... See more keywords
An improved two-stage framework of evidence-based design optimization
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DOI: 10.1007/s00158-018-1991-6
Abstract: In this paper, an improved two-stage framework is presented to handle the evidence-based design optimization (EBDO) problem under epistemic uncertainty. The improvements include two aspects: (1) in the first stage, the equal areas method is… read more here.
Keywords: framework; evidence; design optimization; optimization ... See more keywords
Analytical moment based approximation for robust design optimization
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DOI: 10.1007/s00158-018-2029-9
Abstract: The role of robust design optimization (RDO) has been eminent, ascertaining optimal configuration of engineering systems in the presence of uncertainties. However, computational aspect of RDO can often get tediously intensive in dealing with large… read more here.
Keywords: approximation; optimization analytical; design optimization; optimization ... See more keywords
A simulation-assisted complexity metric for design optimization of integrated architecture aero-engine structures
Sign Up to like & getrecommendations! Published in 2019 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-019-02308-5
Abstract: Traditional metrics for assessing system complexity are based on aspects such as number of and interaction among components. For functionally integrated structures, the application of such metrics can be difficult and/or limited due to the… read more here.
Keywords: design optimization; complexity; integrated architecture;
A new efficient decoupled reliability-based design optimization method with quantiles
Sign Up to like & getrecommendations! Published in 2019 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-019-02384-7
Abstract: The problems of reliability-based design optimization (RBDO) can generally be solved by double-loop methods, single-loop methods or decoupled methods. The sequence optimization and reliability assessment (SORA) method is a widely used decoupled method due to… read more here.
Keywords: reliability based; method; design optimization; optimization ... See more keywords
A multidisciplinary design optimization for conceptual design of hybrid-electric aircraft
Sign Up to like & getrecommendations! Published in 2021 at "Structural and Multidisciplinary Optimization"
DOI: 10.1007/s00158-021-03033-8
Abstract: Aircraft design has become increasingly complex since it depends on technological advances and integration between modern engineering systems. These systems are multidisciplinary, i.e., any process or division of any aircraft design produces effects in all… read more here.
Keywords: aircraft; design optimization; multidisciplinary design; hybrid electric ... See more keywords