Design of PEG-grafted-PLA nanoparticles as oral permeability enhancer for P-gp substrate drug model Famotidine
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DOI: 10.1080/02652048.2017.1290155
Abstract: Abstract Bioavailability of oral drugs can be limited by an intestinal excretion process mediated by P-glycoprotein (P-gp). Polyethylene glycol (PEG) is a known P-gp inhibitor. Dispersion of Famotidine (a P-gp substrate) within PEGylated nanoparticles (NPs)… read more here.
Keywords: design peg; nps prepared; famotidine; permeability ... See more keywords