Design of protein delivery systems by mimicking extracellular mechanisms for protection of growth factors.
Sign Up to like & getrecommendations! Published in 2017 at "Acta biomaterialia"
DOI: 10.1016/j.actbio.2017.08.042
Abstract: Heparin sulfate proteoglycans (HSPGs) are responsible for the storage and stabilization of numerous growth factors in the extracellular matrix. In this complex native environment, the efficient binding of the growth factors is determined by multivalent,… read more here.
Keywords: protection; delivery; growth factors; growth ... See more keywords
Discovery and design of G protein-coupled receptor targeting antibodies
Sign Up to like & getrecommendations! Published in 2023 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2023.2193389
Abstract: ABSTRACT Introduction G protein-coupled receptors (GPCRs) are the target of one-third of all approved drugs; however, these drugs only target about one-eighth of the human repertoire of GPCRs. GPCRs regulate a diverse range of critical… read more here.
Keywords: discovery design; design protein; receptor; protein coupled ... See more keywords
Insights for the design of protein lysine methyltransferase G9a inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0396
Abstract: The epigenetic control of gene expression could be affected by addition and/or removal of post-translational modifications such as phosphorylation, acetylation and methylation of histone proteins, as well as methylation of DNA (5-methylation on cytosines). Misregulation… read more here.
Keywords: insights design; design protein; g9a inhibitors; protein lysine ... See more keywords