Design of a randomized controlled trial for genomic carrier screening in healthy patients seeking preconception genetic testing
Sign Up to like & getrecommendations! Published in 2017 at "Contemporary clinical trials"
DOI: 10.1016/j.cct.2016.12.007
Abstract: Population-based carrier screening is limited to well-studied or high-impact genetic conditions for which the benefits may outweigh the associated harms and costs. As the cost of genome sequencing declines and availability increases, the balance of… read more here.
Keywords: genomic carrier; carrier screening; design randomized; randomized controlled ... See more keywords
Enrichment Bayesian design for randomized clinical trials using categorical biomarkers and a binary outcome
Sign Up to like & getrecommendations! Published in 2022 at "BMC Medical Research Methodology"
DOI: 10.1186/s12874-022-01513-z
Abstract: Background Adaptive clinical trials have been increasingly commonly employed to select a potential target population for one trial without conducting trials separately. Such enrichment designs typically consist of two or three stages, where the first… read more here.
Keywords: clinical trials; binary outcome; randomized clinical; design randomized ... See more keywords
Corrigendum: Basis and Design of a Randomized Clinical Trial to Evaluate the Effect of Jinlida Granules on Metabolic Syndrome in Patients With Abnormal Glucose Metabolism
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DOI: 10.3389/fendo.2020.00649
Abstract: [This corrects the article DOI: 10.3389/fendo.2020.00415.]. read more here.
Keywords: corrigendum basis; clinical trial; design randomized; trial evaluate ... See more keywords
[How to report adaptive design randomized trials-A interpretation of international reporting guideline ACE].
Sign Up to like & getrecommendations! Published in 2022 at "Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi"
DOI: 10.3760/cma.j.cn112338-20210319-00230
Abstract: Concerns has been raised in improving the quality of adaptive design randomized trials reports. Based on the CONSORT 2010 (Consolidated Standards of Reporting Trials), The Adaptive designs CONSORT Extension (ACE) has developed items and reporting… read more here.
Keywords: report adaptive; adaptive design; ace; design ... See more keywords